Biologics for Skeletal Muscle Healing: The Role of Senescence and Platelet-Based Treatment Modalities

Oberlohr, Verena; Lengel, Haylie; Hambright, William S.; Whitney, Kaitlyn E.; Evans, Thos A.; Huard, Johnny

doi:10.1016/j.otsm.2020.150754

Cited by 1 publication

(1 citation statement)

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“…Recently, Oberlohr and associates studied extensively the role of cell senescence in attenuated muscle regeneration, evaluating PRP and platelet poor plasma (PPP) as biological treatment options for skeletal muscle repair. They envisioned that PRP or PPP treatment for skeletal muscle repair will be based on the customization of biological factors by targeting SASP specific cell markers and other factors that attribute to the development of fibrosis [ 175 ].…”

Section: Cell Senescence Aging and Prpmentioning

confidence: 99%

Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

Everts

Onishi²,

Jayaram

et al. 2020

IJMS

512

319

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Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols.

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Section: Cell Senescence Aging and Prpmentioning

confidence: 99%