2010
DOI: 10.1590/s1516-31802010000500013
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Biologics for rheumatoid arthritis: an overview of Cochrane reviews

Abstract: based upon indirect comparisons, anakinra seemed less efficacious than etanercept, adalimumab and rituximab and etanercept seemed to cause fewer withdrawals due to adverse events than adalimumab, anakinra and infliximab. Significant heterogeneity in characteristics of trial populations imply that these finding must be interpreted.

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Cited by 76 publications
(39 citation statements)
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“…); on the cost-effectiveness of the treatment; and, especially, on the consensus that has been reached with the patient, after extensive discussion about the possible benefits, side effects and risks from the treatment. 1,2 …”
Section: Commentsmentioning
confidence: 99%
“…); on the cost-effectiveness of the treatment; and, especially, on the consensus that has been reached with the patient, after extensive discussion about the possible benefits, side effects and risks from the treatment. 1,2 …”
Section: Commentsmentioning
confidence: 99%
“…The effectiveness of DMARDs and biological therapeutics on decreasing disease activity has been established. [2,3] Patients experience life with RA along a continuum from RA in the background to RA in the foreground of their lives, and vice versa. Even if RA is put back to the background of patient's lives by means of disease-modifying agents, most patients still experience continuous, daily symptoms.…”
Section: Introductionmentioning
confidence: 99%
“…Treatment options for RA include nonsteroidal antiinflammatory drugs, glucocorticoids, traditional diseasemodifying antirheumatic drugs (DMARDs), and biologic DMARDs (4). Biologic DMARDs are very effective in treating RA and are commonly used for patients with suboptimal response or intolerance to traditional DMARDs (4).…”
Section: Introductionmentioning
confidence: 99%
“…Biologic DMARDs are very effective in treating RA and are commonly used for patients with suboptimal response or intolerance to traditional DMARDs (4).…”
Section: Introductionmentioning
confidence: 99%