Biologics and acellular dermal matrices in head and neck reconstruction: A comprehensive review

Patel, Shivam; Ziai, Kasra; Lighthall, Jessyka G.; Walen, Scott

doi:10.1016/j.amjoto.2021.103233

Cited by 21 publications

(20 citation statements)

References 54 publications

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“…Most of these characteristics are included in ADMs. More specifically, advantages of dermal substitutes include low immunogenicity after application, temporary or permanent coverage of the skin and soft tissue, elasticity and pliability to contour any tissue defects, minimal application time in the operation room, and minimal patient morbidity, since no harvest sites are required [66].…”

Section: Characteristics and Application Mechanism Of Admmentioning

confidence: 99%

“…A large number of patients with cutaneous malignancies in areas involving the midface, nasal sidewall, and nasal alae are commonly left with a significant defect, which concerns the concomitant loss of volume following wide local excision. In addition to providing a scaffold for wound healing, ADMs, such as AlloDerm, have been shown to effectively restore the volume after full-thickness excisions in the midface and nasal alae [66].…”

Section: Applications In Otorhinolaryngology and Maxilla-facial Surgerymentioning

confidence: 99%

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Advances on the modification and biomedical applications of acellular dermal matrices

et al. 2022

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Acellular dermal matrix (ADM) is derived from natural skin by removing the entire epidermis and the cell components of dermis, but retaining the collagen components of dermis. It can be used as a therapeutic alternative to “gold standard” tissue grafts and has been widely used in many surgical fields, since it possesses affluent predominant physicochemical and biological characteristics that have attracted the attention of researchers. Herein, the basic science of biologics with a focus on ADMs is comprehensively described, the modification principles and technologies of ADM are discussed, and the characteristics of ADMs and the evidence behind their use for a variety of reconstructive and prosthetic purposes are reviewed. In addition, the advances in biomedical applications of ADMs and the common indications for use in reconstructing and repairing wounds, maintaining homeostasis in the filling of a tissue defect, guiding tissue regeneration, and delivering cells via grafts in surgical applications are thoroughly analyzed. This review expectedly promotes and inspires the emergence of natural raw collagen-based materials as an advanced substitute biomaterial to autologous tissue transplantation. Graphical Abstract

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Section: Characteristics and Application Mechanism Of Admmentioning

confidence: 99%

Section: Applications In Otorhinolaryngology and Maxilla-facial Surgerymentioning

confidence: 99%

Advances on the modification and biomedical applications of acellular dermal matrices

et al. 2022

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“…In order to avoid donor site morbidity with STSGs, an ADM may alternatively be selected. AlloDerm is perhaps the most common substitute for STSGs in oropharyngeal reconstruction [33 ▪▪ ]. ADMs provide an effective barrier between the oropharynx and neck when used as an adjunct to local muscle flaps, as shown by Sinha et al [34].…”

Section: Recent Findingsmentioning

confidence: 99%

Oropharyngeal reconstruction after transoral robotic surgery

Silverman

Birkeland

Bewley

2022

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of reviewTransoral robotic surgery (TORS) has experienced an evolution in recent years. This technique has proved to be a safe and effective method for extirpation of select oropharyngeal tumors. Advances in technology as well as improved surgeon experience allow for the resection of larger, more complex cancers. Although healing by secondary intention remains the current standard for limited oropharyngeal defects, larger resections demand reconstruction with vascularized tissue to minimize morbidity and optimize functional outcomes. The objective of this review is to evaluate recent literature regarding oropharyngeal reconstruction after TORS. Recent findingsA variety of reconstructive options to manage oropharyngeal defects exist. Several reconstructive algorithms have been suggested; however, careful consideration must be used to select the most ideal flap type. Locoregional flaps have shown excellent functional outcomes with limited morbidity. An increase in free flap reconstruction has been demonstrated, particularly among patients with larger TORS defects and following chemoradiation therapy. Despite limited data, robotic-assisted flap inset and microvascular anastomosis has recently shown promise. SummaryReconstruction and flap selection following TORS should be tailored to the patient and unique oropharyngeal defect. Functional outcomes are promising with low complication rates among these patients. Keywordsfree flap, locoregional flap, oropharyngeal reconstruction, transoral robotic surgery & ,5]. Importantly, TORS may obviate the need for open surgical approaches and adjuvant therapy, thereby reducing functional morbidity and toxicities [6,7 && ,8].Despite the advantages of robotic-assisted surgery, oropharyngeal resection with TORS may still result in sizeable defects which necessitate reconstruction. As indications for TORS expand to include larger and more complex resections, careful consideration is required to select the most appropriate

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“…It has also been proposed for urology [ 13 ]. It is used in wound dressing and skin reconstruction [ 14 , 15 , 16 ], although other thicker scaffolds from acellular dermal matrix (ADM) are well-established in this application [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Structure and Strength of Bovine and Equine Amniotic Membrane

Wells

Sizeland²,

Kirby³

et al. 2022

Biology

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Thin, strong scaffold materials are needed for surgical applications. New materials are required, particularly those readily available, such as from non-human sources. Bovine amniotic membrane (antepartum) and equine amniotic membrane (postpartum) were characterized with tear and tensile tests. The structural arrangement of the collagen fibrils was determined by small-angle X-ray scattering, scanning electron microscopy, and ultrasonic imaging. Bovine amnion had a thickness-normalized tear strength of 12.6 (3.8) N/mm, while equine amnion was 14.8 (5.3) N/mm. SAXS analysis of the collagen fibril arrangement yielded an orientation index of 0.587 (0.06) and 0.681 (0.05) for bovine and equine, respectively. This may indicate a relationship between more highly aligned collagen fibrils and greater strength, as seen in other materials. Amnion from bovine or equine sources are strong, thin, elastic materials, although weaker than other collagen tissue materials commonly used, that may find application in surgery as an alternative to material from human donors.

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Biologics and acellular dermal matrices in head and neck reconstruction: A comprehensive review

Cited by 21 publications

References 54 publications

Advances on the modification and biomedical applications of acellular dermal matrices

Advances on the modification and biomedical applications of acellular dermal matrices

Oropharyngeal reconstruction after transoral robotic surgery

Structure and Strength of Bovine and Equine Amniotic Membrane

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