Biologically Triggered Delivery of EGF from Polymer Fiber Patches

Kim, Si Eun; Lee, Parker W.; Pokorski, Jonathan K.

doi:10.1021/acsmacrolett.7b00212

Cited by 13 publications

(13 citation statements)

References 41 publications

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“…The EGF‐loaded, MMP‐responsive fiber significantly promoted proliferation and migration of human keratinocytes in the presence of the biological trigger MMP‐9. [ 74 ]…”

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissue mentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

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“…The EGF‐loaded, MMP‐responsive fiber significantly promoted proliferation and migration of human keratinocytes in the presence of the biological trigger MMP‐9. [ 74 ]…”

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissue mentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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“…The developed system provided a prolonged sustained release of rhPDGF for 21 days, which promoted the wound closure. [ 123 ] In another study, Liu and co‐workers fabricated bFGF‐loaded cocrosslinked hydrogel film composed of thiolated derivatives of chondroitin 6‐sulfate and heparin (CS‐HP ECM) as a potent wound dressing for full‐thickness wounds in the db/db mice model. In vivo experiments confirmed the biodegradability and sustained release of bFGF.…”

Section: Evolutionary Trend Of Wound Dressingsmentioning

confidence: 99%

“…The presence of MMP in the early stages of wound healing triggered the release of EGF from the electrospun mesh and promoted the proliferation and migration of human keratinocytes into the wound site. [ 123 ]…”

Section: Evolutionary Trend Of Wound Dressingsmentioning

confidence: 99%

Wound Healing: From Passive to Smart Dressings

Farahani

Shafiee

2021

Adv Healthcare Materials

317

219

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The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on the patients and healthcare systems. Although, the application of traditional wound dressings contributes to an effective wound healing outcome, yet, the complexity of the healing process remains a major health challenge. Recent advances in materials and fabrication technologies have led to the fabrication of dressings that provide proper conditions for effective wound healing. The 3D‐printed wound dressings, biomolecule‐loaded dressings, as well as smart and flexible bandages are among the recent alternatives that have been developed to accelerate wound healing. Additionally, the new generation of wound dressings contains a variety of microelectronic sensors for real‐time monitoring of the wound environment and is able to apply required actions to support the healing progress. Moreover, advances in manufacturing flexible microelectronic sensors enable the development of the next generation of wound dressing substrates, known as electronic skin, for real‐time monitoring of the whole physiochemical markers in the wound environment in a single platform. The current study reviews the importance of smart wound dressings as an emerging strategy for wound care management and highlights different types of smart dressings for promoting the wound healing process.

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“…Kim et al described polymer fiber patches, from which recombinant EGF was engineered, as releasing only in the presence of wound-healing cues, e.g., MMP-9. Results showed that the EGF-loaded responsive fiber significantly promoted proliferation and migration of human keratinocytes in the presence of the biological trigger MMP-9 [ 125 ].…”

Section: Polymer-based Smart Drug Delivery Systems For Topical Applicationsmentioning

confidence: 99%

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

et al. 2021

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Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

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Biologically Triggered Delivery of EGF from Polymer Fiber Patches

Cited by 13 publications

References 41 publications

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Wound Healing: From Passive to Smart Dressings

Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

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