“…Likewise, many simulation reports are there where the researchers have attempted to emulate the biological entities like proteins, DNA, antibodies etc in the simulation platform to investigate the biosensing attributes of the sensor. The various approaches include the representation of neutral biomolecules through its dielectric constant and for charged biomolecules like DNA it is represented by the dielectric constant as well as the charge associated to the biomolecule [118]- [121]. There are many designs reported in the literature such as nanogap embedded cavity, dual cavity, underlap and open gate designs.…”