Abstract:Intratumoral heterogeneity presents a major challenge to diagnosis and treatment of glioblastoma (GBM). Such heterogeneity is further exacerbated upon the recurrence of GBM, where treatment-induced reactive changes produce additional intratumoral heterogeneity that is ambiguous to differentiate on clinical imaging. There is an urgent need to develop non-invasive approaches to map the heterogeneous landscape of histopathological alterations throughout the entire lesion for each patient. We propose to predictive… Show more
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