Biologically active quinazoline-based hydroxamic acids

MSCs as Tumor-Specific Vectors for the Delivery of Anticancer Agents—A Potential Therapeutic Strategy in Cancer Diseases: Perspectives for Quinazoline Derivatives

“…Currently, it is also indicated that multifunctional hybrid compounds containing quinazoline/quinazolinone and other biologically active pharmacophores can potentially significantly increase the effectiveness of pharmacotherapy [ 141 ]. Osipov et al point out that hybrid compounds containing the quinazoline cycle may constitute the basis for the synthesis of effective drugs with great therapeutic potential in the complex treatment of oncological, neurological or infectious diseases [ 142 ]. There are many reports that show the therapeutic potential of various quinazoline/quinazolinone-based hybrid analogues against a wide range of diseases.…”

Diversity in the Interaction of Amino Acid- and Peptide-Based Hydroxamic Acids with Some Platinum Group Metals in Solution

“…For many reasons, investigation of the metal-binding properties of hydroxamic acidbased organic bioligands (containing at least one hydroxamic acid function, R C C(O)R N N(OH), where R C = alkyl or aryl; R N = H in primary derivatives, alkyl or aryl in secondary ones), whether naturally occurring or synthetic, has been a focus of interest for many decades. Most of the results are summarized in excellent reviews, some of which are referred here [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The previous results clearly demonstrate the significance of hydroxamatebased compounds in many fields, for example, they are known to play a crucial role in microbial iron uptake [3,5,6,11] and are capable of inhibiting a variety of enzymes, including ureases, peroxidases, and matrix metalloproteinases [8][9][10]14,16,[18][19][20][21][22][23][24][25].…”

“…Most of the results are summarized in excellent reviews, some of which are referred here [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The previous results clearly demonstrate the significance of hydroxamatebased compounds in many fields, for example, they are known to play a crucial role in microbial iron uptake [3,5,6,11] and are capable of inhibiting a variety of enzymes, including ureases, peroxidases, and matrix metalloproteinases [8][9][10]14,16,[18][19][20][21][22][23][24][25]. In correlation with these biological roles/effects, hydroxamate-based compounds are frequently used in the design of therapeutics targeting different diseases, like iron overload, cancers, microbial infections, inflammations, etc.…”

“…As is already well-known, hydroxamates typically coordinate to metal centers through the carbonyl oxygen atom and the deprotonated hydroxyl group, resulting in the formation of a 5-membered (O,O)-type hydroxamatochelate. Under special conditions however, a few other modes are also known, e.g., binding through the deprotonated nitrogen [12,14,20]. Furthermore, the complexation behaviour of hydroxamic acids can significantly be altered by the presence of additional donors, such as amino group(s) in amino acid derivatives or amino and peptide-amide moieties in peptide derivatives [12,20,34].…”

“…Under special conditions however, a few other modes are also known, e.g., binding through the deprotonated nitrogen [12,14,20]. Furthermore, the complexation behaviour of hydroxamic acids can significantly be altered by the presence of additional donors, such as amino group(s) in amino acid derivatives or amino and peptide-amide moieties in peptide derivatives [12,20,34].…”