Biologically Active Principles of Crude Drugs. Antidiabetic Principles of Corni Fructus in Experimental Diabetes induced by Streptozotocin

Yamahara, Johji; Mibu, Hiroyuki; Sawada, Tokunosuke; Fujimura, Hajimè; Takino, Shingo; Yoshikawa, Masayuki; Kitagawa, Isao

doi:10.1248/yakushi1947.101.1_86

Cited by 42 publications

(24 citation statements)

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“…The extract of Corni Fructus has potent anti-diabetic activity towards streptozotocin-induced diabetic rats. Ursolic acid and oleanolic acid found in the extract were responsible for the activity (Yamahara et al, 1981). Based on decreasing postprandial plasma glucose and insulin level of noninsulin-dependent diabetic rats, further research was carried out.…”

Section: Fructus Coinimentioning

confidence: 99%

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

Zheng

Bukuru

et al. 2004

Journal of Ethnopharmacology

801

524

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Section: Fructus Coinimentioning

confidence: 99%

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

Zheng

Bukuru

et al. 2004

Journal of Ethnopharmacology

801

524

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“…et Zucc., is commonly prescribed in Traditional Chinese Medicine as a tonic formula and considered to possess actions including invigoration of the liver and kidney, preservation of essence, and anti-diabetes (Jayaprakasam et al, 2005). Anti-diabetic activity of Fructus Corni was investigated by employing streptozotocin-induced diabetic rats (Yamahara et al, 1981). By using neonatal STZ-injected animal as a model of NIDDM, the ethanol extract of Fructus Corni resulted in the induction of GLUT4 mRNA and protein expression.…”

Section: Introductionmentioning

confidence: 99%

Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death

Chen

Hsu

Chen³

et al. 2008

Journal of Ethnopharmacology

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“…As to the therapeutic effects of HJ, various human and animal studies have been conducted, [2][3][4][5] most of which examined the effects of HJ on renal damage and the action mechanism for such effects. [6][7][8] Experimentally, HJ has exhibited beneficial effects in patients with diabetes mellitus and in many diabetic animal models, and in particular, it is used in the treatment of dry mouth, thirst, and polyuria associated with diabetes.…”

mentioning

confidence: 99%

Effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on Hyperglycemia in Streptozotocin-Induced Diabetic Rats

Hirotani

Ikeda

Yamamoto

et al. 2007

Biological & Pharmaceutical Bulletin

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The herbal prescription Hachimi-jio-gan (HJ) (Ba-Wei-DiHuang-Wan) has been widely used for the treatment of patients with diabetes mellitus, hypertension, nephrotic syndromes, and glomerulonephritis since the late middle ages. HJ is used as a Kampo formula for diabetes and the package insert for HJ extract for medical use states that HJ suppresses experimentally induced diabetes, inhibits reduction in vascular elasticity due to high-cholesterol diets, hinders aldose reductase activity, and protects the renal tissue of rats that are genetically sensitive to salt. 1)The composition of HJ is as follows: Rehmanniae radix (6 g), Corni fructus (3 g), Dioscoreae rhizoma (3 g), Alismatis rhizoma (3 g), Hoelen (3 g), Moutan cortex (2.5 g), Cinnamomi cortex (1 g), and Aconiti tuber (0.5 g). Animal studies have shown that Rehmanniae radix, Corni fructus and Hoelen lower blood sugar, but HJ does not contain ginseng which is frequently used to treat diabetes in the clinical setting.As to the therapeutic effects of HJ, various human and animal studies have been conducted, 2-5) most of which examined the effects of HJ on renal damage and the action mechanism for such effects. [6][7][8] Experimentally, HJ has exhibited beneficial effects in patients with diabetes mellitus and in many diabetic animal models, and in particular, it is used in the treatment of dry mouth, thirst, and polyuria associated with diabetes. However, details of the mechanism responsible for the effects of HJ against hyperglycemia remain unclear, and there are few scientific studies supporting the effects of HJ on such subjective symptoms to date.Many animal models of diabetes are available, but in the present study, diabetic rats were prepared by administration of streptozotocin (STZ) which is frequently used to prepare insulin-deficiency models. STZ is an antibiotic, antineoplastic agent that has a 2-deoxy-D-glucose molecule connected to an N-nitroso-N-methyl urea group, and it is used to induce diabetes under experimental conditions. The diabetogenic action of STZ was shown to result primarily from its highly specific cytotoxic action on the b-cells of the pancreatic Langerhans' islets. This causes rapid and irreversible necrosis, leading to metabolic alterations associated with the increase of blood glucose and decrease of serum insulin levels and pancreatic insulin contents; i.e., insulin deficiency. STZtreatment thereby sustainably causes hyperglycemia, increase in water and food intake, glycosuria, and decrease in body weight in animals. 9)In this study, we investigated the effects of HJ on hyperglycemia by means of pharmacological and biochemical procedures, using STZ-induced diabetic rats. MATERIALS AND METHODS AnimalsMale Wistar rats (Clea Japan Inc., Tokyo, Japan) weighing 180-190 g were used. Rats were maintained for 1 week on an MF diet (Oriental Yeast, Tokyo, Japan). They had free access to the rat chow and water and were kept in a room maintained at 23Ϯ2°C with a 12 h/12 h light/dark cycle. All experimental procedures were conducted in accord...

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Biologically Active Principles of Crude Drugs. Antidiabetic Principles of Corni Fructus in Experimental Diabetes induced by Streptozotocin

Cited by 42 publications

References 0 publications

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death

Effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on Hyperglycemia in Streptozotocin-Induced Diabetic Rats

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