Biologically active lignans in extract and seeds of Schizandra chinensis

Zhukovich, E. N.; Bokareva, S. Yu.; Sharikova, L. A.; Pribytkova, T. F.; Semenova, M. Yu.; Коровина, Л. М.

doi:10.1007/s11094-007-0020-7

Cited by 3 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies found that the schizandrol A content in the tincture and in the oil extract were approximately identical at about 0.09% [6]. Table 3 gives results from quantitative analysis of total lignans in the tincture, the oil extract, and in raw material.…”

Section: Preparation Of Standard Schizandrol a Solutionmentioning

confidence: 97%

“…Exhaustive extraction of Chinese magnolia-vine seeds by various extractants [hexane, ethylether, ethanol (96% and 20%)] was used earlier to establish that the content of total lignans calculated as schizandrol A varied from 0.6 to 1.3% and averaged 1% [6] whereas the content of total lignans in the tincture was~0.2% with schizandrol A content 0.088% (HPLC) [6].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Investigation of the oil extract of Schizandra seeds

Zhukovich¹,

Semenova²,

Sharikova³

et al. 2008

Pharm Chem J

Self Cite

View full text Add to dashboard Cite

A method for production and standardization of the oil extract of Schisandra chinensis seed has been developed based on isolation of the lignan fraction (with the major constituent schizandrol A) by aqueous ethanol (20%) and spectrophotometric assay. Solutions used for the quantitative assay are concentrated and then used for TLC (qualitative analysis). HPLC data showed that the concentration of the lignan fraction (schizandrol A) amounts to 0.08 -0.11%, which is close to that in commercial tincture (about 0.09%) and that the proposed oil extract can be used as a neurotonic stimulant in the same doses as the tincture.

show abstract

Section: Preparation Of Standard Schizandrol a Solutionmentioning

confidence: 97%

mentioning

confidence: 99%

Investigation of the oil extract of Schizandra seeds

Zhukovich¹,

Semenova²,

Sharikova³

et al. 2008

Pharm Chem J

Self Cite

View full text Add to dashboard Cite

show abstract

Analysis of lignans in Schisandra chinensis fruits, leaves, biomasses from in vitro cultures and food supplements

Ekiert

Szopa

Krzek

et al. 2013

Journal of Functional Foods

View full text Add to dashboard Cite

Investigation of the Component Composition of Carbon Dioxide Extract of Schisandra Chinensis Seeds

Morozov

2022

Mediko-farmacevtičeskij žurnal "Pulʹs"

View full text Add to dashboard Cite

Schisandra chinensis (Turcz.) Baill. of the Schisandraceae family is a bright representative of medicinal plants from the group of classical plant adaptogens. Schisandra chinensis seeds are an official medicinal plant raw material included in the State Pharmacopoeia of the Russian Federation of the 14th edition, on the basis of which it is possible to create new medicines in modern dosage forms capable of having an adaptogenic and general ionizing effect on the human body. However, in the domestic pharmaceutical market, Schisandra preparations are presented only in the form of a traditional tincture, the use of which is limited due to objective reasons. According to many authors, the predominant form for Schisandra seeds is its oil form. We have proposed the main parameters for obtaining carbon dioxide extract under supercritical conditions from Schisandra chinensis seeds. Therefore, the main purpose of this work was to study the component composition of supercritical carbon dioxide extract of Schisandra chinensis seeds. Using the gas chromatography/mass spectrometry method, 41 compounds belonging to various classes were identified in the studied Schisandra extract. It was experimentally established that the content of monoterpenes was 17,38 %, sesquiterpenes 22,45 %, terpenoids (alcohols, esters, ketones) – 14,99 %) and aromatic substances – 1,66 %. The obtained results also indicate the dominant presence of lignans (43,52 %) in the studied extract. Among which the largest number corresponds to schizandrin (15,68 %) and γ-schizandrin (11,44 %). The component composition of the carbon dioxide extract of Schisandra chinensis seeds, both in terms of the qualitative and quantitative content of biologically active substances, allows it to be further considered as an active composition in the development of new dosage forms.

show abstract

Biologically active lignans in extract and seeds of Schizandra chinensis

Cited by 3 publications

References 1 publication

Investigation of the oil extract of Schizandra seeds

Investigation of the oil extract of Schizandra seeds

Analysis of lignans in Schisandra chinensis fruits, leaves, biomasses from in vitro cultures and food supplements

Investigation of the Component Composition of Carbon Dioxide Extract of Schisandra Chinensis Seeds

Contact Info

Product

Resources

About