Biologically active filters – An advanced water treatment process for contaminants of emerging concern

Zhang, Shuangyi; Gitungo, Stephen; Axe, Lisa; Raczko, Robert F.; Dyksen, John E.

doi:10.1016/j.watres.2017.02.014

Cited by 67 publications

(41 citation statements)

References 60 publications

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“… 38 In recent years, combinations of gas chromatography–quadrupole time-of-flight mass spectrometry and liquid chromatography–quadrupole time-of-flight mass spectrometry have been applied successfully in numerous metabolomics studies to achieve more sensitive and accurate metabolic profiling and screening of biomarkers. 39 Gas chromatography–quadrupole time-of-flight mass spectrometry is a possible method that could be used for analyzing the metabolite changes and pathways.…”

Section: Discussionmentioning

confidence: 99%

Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex

Hu¹,

Shen²,

Bai³

et al. 2018

NDT

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PurposeGinkgo biloba extract (GBE) contains diterpene ginkgolides (DGs), which have been shown to have neuroprotective effects by a number of previous studies. We previously demonstrated part of the action of DG. However, the impact of DG on the prefrontal cortex (PFC) remains unclear. Here, we evaluated the effects of DG and venlafaxine (for comparison) on behavioral and metabolite changes in the PFC using mice models and gas chromatography–mass spectrometry-based metabolomics.Materials and methodsMice were randomly divided into control (saline), DG (12.18 mg/kg) and venlafaxine (16 mg/kg) groups. After 2 weeks of treatment, depression and anxiety-related behavioral tests were performed. Metabolic profiles of the PFC were detected by gas chromatography–mass spectrometry.ResultsThe DG group exhibited positive effects in the sucrose preference test. The differential metabolites were mainly related to amino acid metabolism, energy metabolism and lipid metabolism. The results indicated that the DG group exhibited perturbed lipid metabolism, molecular transport and small-molecule biochemistry in the PFC. Compared with the control group, pathway analysis indicated that venlafaxine and DG had similar effects on alanine, aspartate and glutamate metabolism.ConclusionThese findings demonstrate that DG has antidepressant-like, but not anxiolytic-like, effects in mice, suggesting that it might have therapeutic potential for the treatment of major depressive disorder.

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Section: Discussionmentioning

confidence: 99%

Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex

Hu¹,

Shen²,

Bai³

et al. 2018

NDT

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“…There are also existing gaps in knowledge regarding the interaction between the microbiome and the host in vivo – and the pathway of its metabolites – and how their metabolites influence the microenvironment. Metabolomic profiling 28 might help answer these questions.…”

Section: Postinfectious Ibs and Altered Microbiomementioning

confidence: 99%

The role of inflammation in irritable bowel syndrome (IBS)

Soh

Loke

et al. 2018

JIR

226

162

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Irritable bowel syndrome (IBS) is a complex, functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort and altered bowel habits. Despite the global prevalence and disease burden of IBS, its underlying pathophysiology remains unclear. Inflammation may play a pathogenic role in IBS. Studies have highlighted the persistence of mucosal inflammation at the microscopic and molecular level in IBS, with increased recruitment of enteroendocrine cells. Substantial overlaps between IBS and inflammatory bowel disease have also been reported. This review thus aimed to discuss the body of evidence pertaining to the presence of mucosal inflammation in IBS, its putative role in the disease process of IBS, and its clinical relevance. Increased mast cell density and activity in the gut may correlate with symptoms of visceral hypersensitivity. As evidenced by patients who develop postinfectious IBS, infective gastroenteritis could cause systemic inflammation and altered microbiome diversity, which in turn perpetuates a cycle of chronic, low-grade, subclinical inflammation. Apart from mucosal inflammation, neuroinflammation is probably involved in the pathophysiology of IBS via the “gut–brain” axis, resulting in altered neuroendocrine pathways and glucocorticoid receptor genes. This gives rise to an overall proinflammatory phenotype and dysregulated hypothalamic–pituitary–adrenal axis and serotonergic (5-HT) functioning, which could, at least in part, account for the symptoms of IBS. Although a definite and reproducible pattern of immune response has yet to be recognized, further research into anti-inflammatories may be of clinical value.

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“…Effluents of fish farms are another direct source of ECs for surface water (Kim et al, 2017). However, conventional wastewater treatment processes fail in removing ECs (Huber et al, 2005;Rigobello et al, 2013;Zhang et al, 2017;Delgado-Moreno et al, 2019;Rizzo et al, 2019). Taking into account that drinking water (DW) is often produced from surface water and groundwater, the efficacy of ECs removal through drinking water treatment plants (DWTPs) is of utmost importance.…”

Section: Introductionmentioning

confidence: 99%

Prolonged exposure of Stenotrophomonas maltophilia biofilms to trace levels of clofibric acid alters antimicrobial tolerance and virulence

et al. 2019

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Biologically active filters – An advanced water treatment process for contaminants of emerging concern

Cited by 67 publications

References 60 publications

Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex

Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex

The role of inflammation in irritable bowel syndrome (IBS)

Prolonged exposure of Stenotrophomonas maltophilia biofilms to trace levels of clofibric acid alters antimicrobial tolerance and virulence

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