Biologically Active Constituents from Plants of the Genus Xanthium

Linh, Nguyen Thi Thuy; Hà, Nguyễn Thị Thu; Tra, Nguyen Thanh; Anh, Le Thị Tu; Chen, Si‐Bao; Tuyen, Nguyen Van

doi:10.1007/978-3-030-80560-9_4

Cited by 6 publications

(3 citation statements)

References 117 publications

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“…Phytochemical and pharmacological studies of medicinal plants have made substantial progress in recent years, with an emphasis on novel molecules with therapeutic qualities. 11–17 The focus of this section is on publications over the last 40 years that deal with phytochemical investigations of Tupistra species. Up to now, approximately 200 compounds with diverse chemical structures have been isolated from the Tupistra genus, but steroid derivatives have predominated.…”

Section: Phytochemistrymentioning

confidence: 99%

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Linh

Son

2022

Natural Product Communications

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In the current paper, secondary metabolites separated from Tupistra plants have been reviewed. Approximately 200 phytochemicals, classified in various chemical classes of bioactive compounds, have been compiled, along with their sources and references. The most striking feature is that the most frequently isolated compounds have been spirostanol sapogenins, and spirostanol and furostanol saponins, most of which are new in nature. The application of both Tupistra plant extracts and isolated compounds in biological assays is also one of the crucial aims in pharmacological discoveries. Tupistra constituents have demonstrated valuable properties in the field of pharmacology, such as antioxidative, antimicrobial, antidiabetic, and antihepatic activities, but their cytotoxic and anti-inflammatory actions can be considered as the more remarkable. In vivo cancer-related activities of the tested Tupistra samples were mostly based on apoptosis. Further phytochemical investigations, together with extensive assessments of the biological profiles and mechanism of action studies of the components of Tupistra species are to be expected.

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Section: Phytochemistrymentioning

confidence: 99%

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Linh

Son

2022

Natural Product Communications

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“…Many studies have focused on the composition of polar solvent extracts and the chemical compounds identified are sorted into three main groups: phenolics, sesquiterpenes, and diterpenes [ 11 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Furthermore, X. spinosum is recognized for its biological and pharmaceutical activities, imputed to the presence of sesquiterpene lactones called xanthanolides [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. These lactones, provided with a non-cyclic carbon chain and a seven-membered ring, appear to be responsible for cytotoxic [ 29 , 30 , 31 ], antitumor [ 20 , 31 , 32 , 33 ], antibacterial [ 34 , 35 , 36 , 37 ], anti-fungal [ 38 ], anti-leishmaniosis [ 38 ], anti...…”

Section: Introductionmentioning

confidence: 99%

“…These lactones, provided with a non-cyclic carbon chain and a seven-membered ring, appear to be responsible for cytotoxic [ 29 , 30 , 31 ], antitumor [ 20 , 31 , 32 , 33 ], antibacterial [ 34 , 35 , 36 , 37 ], anti-fungal [ 38 ], anti-leishmaniosis [ 38 ], anti-malarial [ 39 ], anti-inflammatory [ 30 ], and anti-ulcer activities [ 40 , 41 ]. In particular, xanthatin, isolated from the aerial parts of X. spinosum , is recognized for antibacterial and antifungal properties [ 37 , 42 ], as well as anti-angiogenesis [ 43 ] and phytotoxic properties [ 21 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Guaianolide Derivatives from the Invasive Xanthium spinosum L.: Evaluation of Their Allelopathic Potential

2022

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Ziniolide, xantholide B (11α-dihydroziniolide), and 11β-dihydroziniolide, three sesquiterpene lactones with 12,8-guaianolide skeletons, were identified as volatile metabolites from the roots of Xanthium spinosum L., an invasive plant harvested in Corsica. Essential oil, as well as hydrosol and hexane extracts, showed the presence of guaianolide analogues. The study highlights an analytical strategy involving column chromatography, GC-FID, GC-MS, NMR (1D and 2D), and the hemi-synthesis approach, to identify compounds with incomplete or even missing spectral data from the literature. Among them, we reported the 1H- and 13C-NMR data of 11β-dihydroziniolide, which was observed as a natural product for the first time. As secondary metabolites were frequently involved in the dynamic of the dispersion of weed species, the allelopathic effects of X. spinosum root’s volatile metabolites were assessed on seed germination and seedling growth (leek and radish). Essential oil, as well as hydrosol- and microwave-assisted extracts inhibited germination and seedling growth; root metabolite phytotoxicity was demonstrated. Nevertheless, the phytotoxicity of root metabolites was demonstrated with a more marked selectivity to the benefit of the monocotyledonous species compared to the dicotyledonous species. Ziniolide derivatives seem to be strongly involved in allelopathic interactions and could be the key to understanding the invasive mechanisms of weed.

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Phytochemical Small Molecules as Potential Anti-angiogenesis Targeted Therapy for Triple-Negative Breast Cancer

Poh-Yen

2023

Rev. Bras. Farmacogn.

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Biologically Active Constituents from Plants of the Genus Xanthium

Cited by 6 publications

References 117 publications

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Genus Tupistra: A Comprehensive Review of Phytochemistry and Pharmacological Activity

Guaianolide Derivatives from the Invasive Xanthium spinosum L.: Evaluation of Their Allelopathic Potential

Phytochemical Small Molecules as Potential Anti-angiogenesis Targeted Therapy for Triple-Negative Breast Cancer

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