“…Since the first report of a solid‐phase synthesis by Merrifield,2 simply repeated cycles of coupling reactions and deprotections have been applied to the automated syntheses of biopolymers such as oligopeptides,2 oligonucleotides,3 and, more recently, oligosaccharides 4. 5 In recent years, automation has also been utilized for applications such as the optimization of reaction conditions, routine syntheses of structurally similar compounds, such as building blocks for combinatorial synthesis,6 and the bulk synthesis of important intermediates. In the total syntheses of complex molecules, however, one needs long sequences that include not only simple transformations but also challenging key reactions.…”