Biologically Active Compounds from the Genus Uncaria (Rubiaceae)

Ravipati, Anjaneya S.; Reddy, N. Venkata; Koyyalamudi, Sundar Rao

doi:10.1016/b978-0-444-63430-6.00013-8

Cited by 16 publications

(8 citation statements)

References 83 publications

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“…In the case of B. amurensis extract, BaB displayed higher reductive capacity (Table 3), as well as a higher EDA (Table 2) than BaL, although BaB contained a lower level of TPC and TFC compared to BaL (Table 1). One of the possibilities for this non-correlation is that some of the polyphenols, which exist in BaB, are extremely active owing to their structural characteristics even if they are present in smaller quantities [22] . Other possibilities are that non-polyphenol-type compounds such as polysaccharides, which possess strong antioxidant activities [23] , might be the active compounds in BaB.…”

Section: Resultsmentioning

confidence: 99%

In vitro screening for antioxidant, antimicrobial, and antidiabetic properties of some Korean native plants on Mt. Halla, Jeju Island

Hyun¹,

Hc²,

Js³

2015

Indian J Pharm Sci

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In this study, Prunus padus, Lonicera caerulea, Berberis amurensis, and Ribes maximowiczianum, which are mainly distributed on Mt. Halla, Jeju Island, have been investigated for their antioxidant, antimicrobial, and antidiabetic activities. The methanol extracts of R. maximowiczianum leaves and P. padus branches exhibited significant and dose-dependent antioxidant activity including electron-donation ability and reducing power. To analyze the antimicrobial activity, each extract was tested by a serial two-fold dilution method against five selected gram-positive bacteria and four gram-negative bacteria, and this suggested that P. padus branches possessed the maximum antimicrobial activity against most of the gram-positive bacteria tested. In addition, the methanol extracts of P. padus branches exhibited the highest α-glucosidase inhibitory activity with an IC 50 value of 1.0±0.1 μg/ml, indicating that P. padus is a promising source as a herbal medicine.

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Section: Resultsmentioning

confidence: 99%

In vitro screening for antioxidant, antimicrobial, and antidiabetic properties of some Korean native plants on Mt. Halla, Jeju Island

Hyun¹,

Hc²,

Js³

2015

Indian J Pharm Sci

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“…Previous phytochemical studies showed that URCU was rich in alkaloids, especially monoterpene indole alkaloids, such as rhynchophylline and isorhynchophylline 5 . Meanwhile, rutin and epicatechin were abundant flavonoids distributed in URCU 32 . Furthermore, the triterpenoids isolated in URCU were mainly oleanolane pentacyclic and ursane pentacyclic triterpenoids, represented by oleanolic acid and ursolic acid, respectively 5 .…”

Section: Resultsmentioning

confidence: 98%

“…5 Meanwhile, rutin and epicatechin were abundant flavonoids distributed in URCU. 32 Furthermore, the triterpenoids isolated in URCU were mainly oleanolane pentacyclic and ursane pentacyclic triterpenoids, represented by oleanolic acid and ursolic acid, respectively. 5 In this study, representative compounds of various types were isolated and identified for activity testing and HPLC analysis.…”

Section: Molecular Dockingmentioning

confidence: 95%

Identification of antidiabetic components in Uncariae Rammulus Cum Uncis based on phytochemical isolation and spectrum–effect relationship analysis

Liu

Wang

Jiang

et al. 2022

Phytochemical Analysis

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Objectives: Uncariae Rammulus Cum Uncis (URCU) is a commonly used herbal medicine to treat diabetes. This work is aimed to discover and identify the antidiabetic components from URCU extract.Methods: Column chromatography and recrystallisation were used to separate individual compounds from URCU extract, and the obtained individual compounds were used for determination of α-glucosidase inhibitory activity. Molecular docking was applied to predict the molecular interactions. High-performance liquid chromatography (HPLC) was used for fingerprint analysis of 12 batches of URCU. HPLC fingerprints were assessed by the similarity analysis (SA) and hierarchical clustering analysis (HCA). The spectrum-effect relationship analysis of URCU was assessed by orthogonal partial least squares (OPLS) and bivariate correlation analysis (BCA).Results: A total of 10 potential bioactive compounds were isolated and six of them showed potent α-glucosidase inhibitory activity (IC 50 = 4.21-166.10 μM). The molecular docking results revealed that the binding energy was consistent with the results of α-glucosidase inhibition activity analysis (À8.55 to À4.84 kcal/mol).The ethanol extracts of the 12 batches of URCU showed inhibitory effect on α-glucosidase in a dose-dependent manner, and the IC 50 values ranged from 0.94 μg/mL to 12.57 μg/mL. The spectrum-effect relationship analysis results indicated that 13 peaks might be potential antidiabetic compounds in URCU, including 18 (hyperoside) and 19 (rutin). Conclusion: A comprehensive connection between URCU chemical components andα-glucosidase inhibitory activity was established for the first time by using a spectrum-effect relationship model, which might be applicable to the quality control of URCU.

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“…Structures were sourced and verified from the literature, Reaxys, PubChem, Google Scholar, and SciFinder. A number of existing reviews were referenced citing the entire or multiple plant species within the Uncaria genus [11,12,14,[24][25][26][27][28][29][30][31], and one recent review focused directly on U. tomentosa constituents and bioactivity [13]. The information in these reviews were corroborated before being reported here, and minor errors in which constituents were wrongly assigned to the species U. tomentosa are also noted in this review.…”

Section: Methodsmentioning

confidence: 99%

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

Blanck¹,

Huebner²,

Rolls³

et al. 2022

AppliedChem

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Cat’s claw (Uncaria tomentosa (Willd. ex Schults) DC.), a plant that is exceptionally rich in phytochemicals, has been used for centuries by the indigenous people of South and Central America as a therapeutic and is currently widely exported for medicinal purposes. Extracts and individual components have shown considerable potential as antibacterials in the literature. The purpose of this review is twofold: first, to provide a substantiated, comprehensive collection of the known chemical constituents of U. tomentosa, including their detailed structures; second, to identify those components that offer some promise as antibacterials based on the research to date. Bacterial resistance to currently available antibiotics continues to increase and is widely recognized as an impending, potentially catastrophic, problem. There is research to suggest that U. tomentosa components may have antibacterial potential individually or synergistically with established antibiotics against microbes, including Borrelia burgdorferi, the causative agent of Lyme disease. It is our intention that this review will provide a valuable resource to investigators in search of new antimicrobials to meet the daunting challenge of antibiotic resistance.

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Biologically Active Compounds from the Genus Uncaria (Rubiaceae)

Cited by 16 publications

References 83 publications

In vitro screening for antioxidant, antimicrobial, and antidiabetic properties of some Korean native plants on Mt. Halla, Jeju Island

In vitro screening for antioxidant, antimicrobial, and antidiabetic properties of some Korean native plants on Mt. Halla, Jeju Island

Identification of antidiabetic components in Uncariae Rammulus Cum Uncis based on phytochemical isolation and spectrum–effect relationship analysis

Comprehensive Review of the Components in Cat’s Claw (Uncaria tomentosa) and Their Antibacterial Activity

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