Biologically active compounds from Lamiaceae family: Central nervous system effects

Abdelhalim, Abeer; Hanrahan, Jane R.

doi:10.1016/b978-0-12-819485-0.00017-7

Cited by 9 publications

(6 citation statements)

References 208 publications

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“…Apigenin is obtained from Teucrium polium L., Melissa officinalis , and Salvia officinalis and belongs to the Lamiaceae family. 154 , 155 It is a traditional herb which is used to treat various types of cancers like prostate cancer, cervical cancer, leukemia, pancreatic cancer, breast cancer, liver cancer, and lung cancer. 156 A current study showed that apigenin decreases the incidence of SC.…”

Section: Therapeutic Strategies For the Treatment Of Skin Cancermentioning

confidence: 99%

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

Dachani,

Kaleem,

Mujtaba

et al. 2024

ACS Omega

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Skin cancer (SC) poses a global threat to the healthcare system and is expected to increase significantly over the next two decades if not diagnosed at an early stage. Early diagnosis is crucial for successful treatment, as the disease becomes more challenging to cure as it progresses. However, identifying new drugs, achieving clinical success, and overcoming drug resistance remain significant challenges. To overcome these obstacles and provide effective treatment, it is crucial to understand the causes of skin cancer, how cells grow and divide, factors that affect cell growth, and how drug resistance occurs. In this review, we have explained various therapeutic approaches for SC treatment via ligands, targeted photosensitizers, natural and synthetic drugs for the treatment of SC, an epigenetic approach for management of melanoma, photodynamic therapy, and targeted therapy for BRAFmutated melanoma. This article also provides a detailed summary of the various natural drugs that are effective in managing melanoma and reducing the occurrence of skin cancer at early stages and focuses on the current status and future prospects of various therapies available for the management of skin cancer.

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Section: Therapeutic Strategies For the Treatment Of Skin Cancermentioning

confidence: 99%

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

Dachani,

Kaleem,

Mujtaba

et al. 2024

ACS Omega

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“…This plant family exhibited anti-oxidant 11 , anti-tumor 12 , anti-fungal 11 , anti-inflammatory 13 , and pain relieving 14 activities. Moreover, the phytochemicals derived from Lamiaceae have shown promising effects CNS-related conditions 15 . In terms of mental health, extracts from Salvia Rosmarinus and Nepeta menthoides have been found to reduce anxiety and depression 16 – 18 , while Salvia officinalis phytochemicals have shown potential in attenuating substance abuse dependency 18 .…”

Section: Introductionmentioning

confidence: 99%

In silico anti-alzheimer study of phytochemicals from Lamiaceae family through GSK3-β inhibition

Zareei,

Pourmand,

Eskandarzadeh

et al. 2024

Sci Rep

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Glycogen synthase kinase 3-beta (GSK3-β) is a serine-threonine protease expressed in the brain, and its hyperactivity is considered the underlying cause of Alzheimer’s disease. This enzyme requires an ATP molecule in its N-terminal lobe to phosphorylate its substrates, with the most important substrate being the Tau protein. This study focuses on the inhibitory mechanism of four naturally occurring compounds—apigenin, luteolin, rosmarinic acid, and salvianolic acid—from the Laminaceae family against GSK3-β. The orientation of the ligands within the ATP-binding pocket of GSK3-β and their binding energy were determined through molecular docking. Additionally, molecular dynamics simulations was conducted to study the conformational changes induced by the ligands in the protein structure. The results showed that apigenin and salvianolic acid achieved deeper parts of the cavity compared to luteolin and rosmarinic acid and formed stable complexes with the enzyme. In the rosmarinic acid complex, the enzyme exhibited the most exposed conformation. On the other hand, luteolin binding caused a small closure of the opening, suggesting a potentially ATP-competitive role. Our results suggest these compounds as lead candidates for the design of GSK3-β inhibitors.

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“…Solenostemon monostachyus P. Beauv (Lamiaceae) is among plants reportedly used in West and Central African ethnomedicine for the treatment and management of various health problems. 4 It occurs as an annual weed in anthropogenic habitats and rocky savannahs. It is slightly succulent, aromatic, and has been reported to reach a height of 100 cm.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening of Solenostemon monostachyus and the Effect of Extract and Fractions on Castor Oil-Induced Diarrhoea in Rats

2021

TJNPR

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antipyretic and antimalarial, 15 anti-inflammatory and antinociceptive, 16 hepatoprotective and nephroprotective 17 and antidepressant properties. 18 Phytoconstituents including diterpenoids, 19 flavonoids, coumarin, and polyphenol 9 have so far been isolated. The leaf essential oil contains β-pinene, oct-1-en-3-ol, β caryophyllene, octan-3-ol, and (E, E)-α-farnesene. 5 The study report, antidiarrhoeal potential of S. monostachyus to provide scientific basis for its use in ethnomedicine for diarrhoeal conditions. Materials and Methods Plant materialsLeaves of the plant were harvested from a forest in Akwa Ibom State, Nigeria, on the 24th October 2014. The plant was identified and authenticated in the Department of Botany, University of Uyo, Uyo. Nigeria. Herbarium specimen (FPUU 573) was deposited at Faculty of Pharmacy Herbarium. The plant was dried on laboratory table for 2 weeks and reduced to powder. The powder (700g) was macerated in 95% ethanol (300ml) for 72 hours. This was further partitioned using chloroform to obtain the chloroform and aqueous extracts. The liquid filtrates obtained were concentrated in vacuo at 40°C. The extracts were stored in a refrigerator until used for experiments. Phytochemical analysesPreliminary phytochemical analysis for the determination of Alkaloids, Flavonoids, Tannins, Anthraquinone, Deoxy-sugar, Cardiac glycosides, Terpenes and Saponin was conducted according to methods described by Harborne; Trease and Evans. 20,21 Animals Wistar rats (105-165g) of either sex were obtained from the University of Uyo animal house. They were maintained on standard animal pellets and water ad libitum. The approval for animal studies were obtained from the

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Biologically active compounds from Lamiaceae family: Central nervous system effects

Cited by 9 publications

References 208 publications

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

In silico anti-alzheimer study of phytochemicals from Lamiaceae family through GSK3-β inhibition

Phytochemical Screening of Solenostemon monostachyus and the Effect of Extract and Fractions on Castor Oil-Induced Diarrhoea in Rats

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