Biologically active compounds from<i>Ozothamnus leptophyllus</i>

Wood, Jackie E; Munro, Murray H. G.; Blunt, John W.; Perry, Nigel B.; Walker, John R.; Ward, Josephine M.

doi:10.1080/0028825x.1999.9512622

Cited by 5 publications

(3 citation statements)

References 22 publications

(36 reference statements)

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“…They are biologically active compounds with known antibacterial [14, 15], antifilarial [16], antiviral [17, 18], antileishmanial [19], and cytotoxic [20, 21] activities.…”

Section: Discussionmentioning

confidence: 99%

Cajachalcone: An Antimalarial Compound fromCajanus cajanLeaf Extract

Ajaiyeoba

Ogbole

Abiodun

et al. 2013

Journal of Parasitology Research

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Cajanus cajan L, a member of the family Fabaceae, was identified from the Nigerian antimalarial ethnobotany as possessing antimalarial properties. The bioassay-guided fractionation of the crude methanol extract of C. cajan leaves was done in vitro using the multiresistant strain of Plasmodium falciparum (K1) in the parasite lactate dehydrogenase assay. Isolation of compound was achieved by a combination of chromatographic techniques, while the structure of the compound was elucidated by spectroscopy. This led to the identification of a cajachalcone, 2′,6′-dihydroxy-4-methoxy chalcone, as the biologically active constituent from the ethyl acetate fraction. Cajachalcone had an IC50 value of 2.0 μg/mL (7.4 μM) and could be a lead for anti-malarial drug discovery.

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“…They are biologically active compounds with known antibacterial [14, 15], antifilarial [16], antiviral [17, 18], antileishmanial [19], and cytotoxic [20, 21] activities.…”

Section: Discussionmentioning

confidence: 99%

Cajachalcone: An Antimalarial Compound fromCajanus cajanLeaf Extract

Ajaiyeoba

Ogbole

Abiodun

et al. 2013

Journal of Parasitology Research

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“…Naturally occurring chalcones (1,3‐diaryl‐2‐propen‐1‐one) are the key intermediates for various plant metabolites. They are biologically active compounds with known antibacterial (2,3), antifilarial (4), antiviral (5,6), antileishmanial (7), and cytotoxic (8,9) activities. Licochalcone A, a natural compound isolated from Chinese licorice roots, has shown potent antiplasmodial activity (10).…”

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confidence: 99%

Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro

et al. 2012

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Twenty‐seven novel chalcone derivatives were synthesized using Claisen‐Schmidt condensation and their antimalarial activity against asexual blood stages of Plasmodium falciparum was determined. Antiplasmodial IC50 (half‐maximal inhibitory concentration) activity of a compound against malaria parasites in vitro provides a good first screen for identifying the antimalarial potential of the compound. The most active compound was 1‐(4‐benzimidazol‐1‐yl‐phenyl)‐3‐(2, 4‐dimethoxy‐phenyl)‐propen‐1‐one with IC50 of 1.1 μg/mL, while that of the natural phytochemical, licochalcone A is 1.43 μg/mL. The presence of methoxy groups at position 2 and 4 in chalcone derivatives appeared to be favorable for antimalarial activity as compared to other methoxy‐substituted chalcones. Furthermore, 3, 4, 5‐trimethoxy groups on chalcone derivative probably cause steric hindrance in binding to the active site of cysteine protease enzyme, explaining the relative lower inhibitory activity.

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“…Some species are aromatic and have been examined for their potentially economically interesting secondary compounds (e.g. Wood et al, 1999) while others are ornamental (Ko et al, 1996).…”

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confidence: 99%

Phylogenetic relationships of the Australasian shrubby everlastings Ozothamnus and Cassinia (Asteraceae: Asteroideae: Gnaphalieae)

Schmidt‐Lebuhn

Constable

2012

Cladistics

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The first comprehensive phylogenetic study of the Australasian shrubby everlastings Ozothamnus, Cassinia, and their satellite genera is presented based on the nuclear ribosomal external and internal transcribed spacer and three chloroplast spacer regions (matK‐psbA, psbA‐trnH, ycf6‐pbsM). While the hypothesis of the monophyly of the sequence copies found in Cassinia cannot be rejected, sequences from Ozothamnus are found to be non‐monophyletic in three possible taxonomic circumscriptions of that genus. Cassinia, Calomeria, Odixia and Haeckeria are nested in a narrowly circumscribed Ozothamnus. Ozothamnus section Hebelaena, a sub‐shrubby group long recognized as potentially misplaced in the genus, is more heterogeneous than expected and is found to be potentially polyphyletic. Perhaps more surprisingly, a group of four species previously considered part of “core” Ozothamnus is found to be more closely related to other genera. It includes the subalpine “cascade everlastings” of south‐eastern Australia. Although many characters traditionally used for the delimitation of genera are homoplasious, connivent involucral bracts and presence of paleae are synapomorphies for Cassinia. Except for the robust shrubby habit, no morphological synapomorphy for core Ozothamnus/Cassinia is currently evident. Future studies are needed to test these results with additional data, to identify morphological and anatomical synapomorphies for individual clades and to resolve species‐level relationships with more extensive sampling to address the possibilities of incomplete lineage sorting or reticulate evolution.

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Biologically active compounds fromOzothamnus leptophyllus

Cited by 5 publications

References 22 publications

Cajachalcone: An Antimalarial Compound fromCajanus cajanLeaf Extract

Cajachalcone: An Antimalarial Compound fromCajanus cajanLeaf Extract

Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro

Phylogenetic relationships of the Australasian shrubby everlastings Ozothamnus and Cassinia (Asteraceae: Asteroideae: Gnaphalieae)

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