Biologically Active Compounds From Diatoms

Lincoln, Ruth A.; Strupinski, Kazimierz; Walker, John M.

doi:10.1080/0269249x.1990.9705124

Cited by 18 publications

(7 citation statements)

References 24 publications

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“…These include antibacterial and antifungal compounds [114][115][116], which are present in FA extracts [117,118]. Antibacterial activity extracted from Skeletonema costatum was shown to inhibit the growth of Vibrio, a pathogen of fish and shellfish [118].…”

Section: Antipathogenic or Medical Applications Of Extracted Diatom Cmentioning

confidence: 99%

The place of diatoms in the biofuels industry

et al. 2012

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Section: Antipathogenic or Medical Applications Of Extracted Diatom Cmentioning

confidence: 99%

The place of diatoms in the biofuels industry

et al. 2012

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“…Microtubule-inhibiting compounds have been described from the Cyanophyta, Chlorophyta and Pyrrophyta (Lincoln et al 1990, Blokhin et al 1995. Inhibitors of microtubule assembly, such as colchicine, are capable of inhibiting sperm motility (HaimovKochman & Ben-Chetrit 1998).…”

Section: Discussionmentioning

confidence: 99%

First evidence of sperm motility inhibition by the diatom aldehyde 2E,4E-decadienal

Caldwell

Bentley²,

Olive³

2004

Mar. Ecol. Prog. Ser.

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Diatoms synthesise bioactive unsaturated short-chain aldehydes (SCAs) in response to wound-activation. The defensive SCAs are toxic to developmental stages of a range of invertebrate species including copepods, sea urchins, polychaetes and ascidians. Embryotoxicity is dose-dependent, with inhibition of cleavage, a reduction in hatching success, and teratogenic effects in neonates symptomatic. Bioactivity is directed at cellular and molecular targets. Diatom extracts and the SCA 2E,4E-decadienal (DD) affect microtubule and microfilament stability. Bioactivity is not restricted to embryogenesis, but has also been demonstrated to affect fertilization success in broadcast-spawning macroinvertebrates. This study has sought to further identify the responses of marine invertebrate gametes and the process of fertilization to DD exposure with particular reference to sperm motility. Incubation of gametes with the saturated aldehydes decanal and undecanal and the fatty acid 5, 8,11,14,17-eicosapentaenoic acid (EPA) did not affect fertilization success. Exposure of gametes to DD inhibits fertilization success in a dose-dependent manner. Fertilization rate declined to 50% of control values at concentrations of 1.55 µg ml -1 for Arenicola marina, 3.98 µg ml -1 for Nereis virens, 7.94 µg ml -1 for Psammechinus miliaris and 10 µg ml -1 for Asterias rubens. Pre-incubation of oocytes in DD affected fertilization success to a limited degree; however pre-incubation of sperm in DD caused a pronounced dose-and time-dependent decline. DD exposure inhibits sperm migration rates and flagellar beating at concentrations as low as 0.05 µg ml -1 . The sperm remained alive, as evidenced by oscillation of the sperm head; however, flagellar beating was inhibited. The negative effect of DD exposure was further enhanced as sperm density was reduced. Analysis by general linear model revealed a significant interaction between DD concentration, period of sperm exposure and fertilizing sperm density (F = 6.7, p = 0.01). We suggest that diatom-derived SCAs can significantly impact fertilization success in broadcast-spawning invertebrates. The identification of sperm motility inhibition as a symptom of DD exposure offers a potentially useful cellular model to further study the effects of novel diatom-derived bioactive molecules.

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“…1997), both in the plankton and in the benthos, few species are cultured in aquaculture plants or for relevant biotechnology products (Borowitzka 1994). Microalgae and, in particular, diatoms are known to produce very large, not yet completely elucidated sets of secondary metabolites (Lincoln et al. 1990, Nappo et al.…”

mentioning

confidence: 99%

“…Despite their abundance and diversity in nature (Norton et al 1996, van den Hoek et al 1997, both in the plankton and in the benthos, few species are cultured in aquaculture plants or for relevant biotechnology products (Borowitzka 1994). Microalgae and, in particular, diatoms are known to produce very large, not yet completely elucidated sets of secondary metabolites (Lincoln et al 1990, Nappo et al 2009). While there is a good understanding of cultivation techniques to be applied to both planktonic and benthic diatoms, the effects and interactions of selected environmental conditions on the population dynamics and the productive yields of cultivated diatoms are yet to be fully understood (de la Peña 2007).…”

mentioning

confidence: 99%

CULTURE CONDITIONS INFLUENCE THE GROWTH DYNAMICS AND THE PRODUCTION OF COCCONEIS SCUTELLUM (BACILLARIOPHYTA)¹

Zupo

Patalano

Messina

2011

Journal of Phycology

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The optimal conditions for the growth of two conspecific benthic diatoms were defined through factorial experimentation. We investigated the roles of light spectrum, nutrient availability, and culture conditions on the laboratory production of Cocconeis scutellum scutellum Ehrenb. and C. scutellum parva Grunow. Diatoms were cultivated in petri dishes, and inverted optical microscopy was used to periodically record their abundance. Growth curves were constructed from these data for each culture condition. In addition, at the end of the experiment we performed weight measurements to determine the total production for each of the considered conditions. We found that cultivation in nonsealed (NS) petri dishes (permitting gas exchange) represented the most productive technique. Cell density and biomass varied among light spectra, although this effect was inconsistent. For example, the Sylvania Gro-Lux lamp (GL) produced the lowest cell density but highest biomass, suggesting that it may promote the production of larger cells. Surprisingly, of the culture media tested, f/2 (a media commonly used for the culture of diatoms) was the least productive. Diatom density and biomass were variably dependent on the combination of experimental culture conditions and strain used. These physical and chemical factors act mainly on given features of the diatom growth curve. These results permitted us to devise adequate culture protocols, to produce a biotechnologically important substance: a proapoptotic compound that specifically destroys the androgenic gland of a shrimp and could find novel applications in human medicine.

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Biologically Active Compounds From Diatoms

Cited by 18 publications

References 24 publications

The place of diatoms in the biofuels industry

The place of diatoms in the biofuels industry

First evidence of sperm motility inhibition by the diatom aldehyde 2E,4E-decadienal

CULTURE CONDITIONS INFLUENCE THE GROWTH DYNAMICS AND THE PRODUCTION OF COCCONEIS SCUTELLUM (BACILLARIOPHYTA)¹

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Biologically Active Compounds From Diatoms

Cited by 18 publications

References 24 publications

The place of diatoms in the biofuels industry

The place of diatoms in the biofuels industry

First evidence of sperm motility inhibition by the diatom aldehyde 2E,4E-decadienal

CULTURE CONDITIONS INFLUENCE THE GROWTH DYNAMICS AND THE PRODUCTION OF COCCONEIS SCUTELLUM (BACILLARIOPHYTA)1

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CULTURE CONDITIONS INFLUENCE THE GROWTH DYNAMICS AND THE PRODUCTION OF COCCONEIS SCUTELLUM (BACILLARIOPHYTA)¹