BIOLOGICAL VARIATION OF INTERLEUKIN 6 (IL-6) AND SOLUBLE INTERLEUKIN 2 RECEPTOR (sIL2R) IN SERUM OF HEALTHY INDIVIDUALS

Cava, Fernando; González, C.; Pascual, Marı́a; Navajo, José Alejandro; González-Buitrago, José Manuel

doi:10.1006/cyto.2000.0714

Cited by 44 publications

(37 citation statements)

References 5 publications

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“…A possible explanation for the discrepancy between CRP and IL-6 is the substantial intraindividual variation in levels of IL-6. 29 Although associations with different measures of atherosclerosis are more consistent for CRP than for IL-6, it is likely that levels of CRP reflect general inflammatory activity. However, specific actions of CRP itself may also be involved in atherogenesis.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Mediators and Cell Adhesion Molecules as Indicators of Severity of Atherosclerosis

Meer

Maat

Bots

et al. 2002

ATVB

156

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Abstract-Inflammatory mediators and soluble cell adhesion molecules predict cardiovascular events. It is not clear whether they reflect the severity of underlying atherosclerotic disease. Within the Rotterdam Study, we investigated the associations of C-reactive protein (CRP), interleukin-6 (IL-6), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 with noninvasive measures of atherosclerosis. Levels of CRP were assessed in a random sample of 1317 participants, and levels of IL-6 and soluble cell adhesion molecules were assessed in a subsample of 714 participants. In multivariate analyses, logarithmically transformed CRP (regression coefficient [␤]ϭϪ0.023, 95% CI Ϫ0.033 to Ϫ0.012) and IL-6 (␤ϭϪ0.025, 95% CI Ϫ0.049 to Ϫ0.001) were inversely associated with the ankle-arm index. Only CRP was associated with carotid intima-media thickness (␤ϭ0.018, 95% CI 0.010 to 0.027). Compared with the lowest tertile, the odds ratio for moderate to severe carotid plaques associated with levels of CRP in the highest tertile was 2.0 (95% CI 1.3 to 3.0). Soluble intercellular adhesion molecule-1 levels were strongly associated with carotid plaques (odds ratio 2.5, 95% CI 1.5 to 4.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Mediators and Cell Adhesion Molecules as Indicators of Severity of Atherosclerosis

Meer

Maat

Bots

et al. 2002

ATVB

156

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“…Factors reported to potentially affect the accuracy of plasma IL-6 results are frequency [115] and mode [116] of collection. Cava et al [115] recently assayed plasma IL-6 concentrations at monthly intervals over a 6-month period.…”

Section: Discussionmentioning

confidence: 99%

“…Cava et al [115] recently assayed plasma IL-6 concentrations at monthly intervals over a 6-month period. The within-subject correlation across samples was relatively low (0.37), leading this group to recommend multiple samples be collected over time for assay of this cytokine, as in this study.…”

Section: Discussionmentioning

confidence: 99%

Plasma and Cerebrospinal Fluid Interleukin-6 Concentrations in Posttraumatic Stress Disorder

Baker

Ekhator

Kasckow

et al. 2001

Neuroimmunomodulation

204

113

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Background: Interleukin-6 (IL-6) secretion is suppressed by glucocorticoids and stimulated by catecholamines. Patients with posttraumatic stress disorder (PTSD) have decreased cortisol and increased catecholamine secretion. The purpose of this study was to assess the relation of IL-6 levels and hypothalamic-pituitary-adrenal and noradrenergic activity in patients with well-characterized PTSD. Methods: Cerebrospinal fluid (CSF) was withdrawn via a lumbar subarachnoid catheter over 6 h from 11 combat veterans with PTSD and 8 age- and sex-matched healthy controls. Blood was withdrawn concurrently. We measured IL-6, CRH and norepinephrine concentrations in the CSF and IL-6, ACTH, cortisol and norepinephrine in plasma. Results: Mean and median CSF IL-6 concentrations were higher in PTSD than in controls (mean = 24.0 vs. 14.6, p = 0.05; median = 26.7 vs. 14.3, p < 0.03): plasma IL-6 concentrations, however, were not different between the two groups. Plasma IL-6 and norepinephrine were positively correlated in the PTSD group (r = +0.74, p < 0.04), but not in normals (r = –0.55, p = 0.20). Conclusions: PTSD patients have increased CSF concentrations of IL-6. Their plasma IL-6 is not elevated but is more tightly associated with noradrenergic output in these patients than in normals. Both findings might be explained by the low cortisol secretion previously reported in PTSD as a result of lowered glucocorticoid suppression of IL-6 secretion. High levels of CSF IL-6 may reflect neurodegeneration or compensatory neuroprotection.

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“…There are only a few longitudinal studies in which repeated samples have been taken from the same subjects over a period supposedly free of inflammatory clinical events. Variable results have been obtained for IL-6 with reliability coefficients ranging from .87 to .37 (Cava et al, 2000;Rao et al, 1994;Tsirpanlis et al, 2004). The intrinsic biologic variability of inflammatory biomarkers can represent a serious caveat in cross-sectional studies if it is not controlled for by appropriate validation procedures.…”

Section: Standardized Assessmentsmentioning

confidence: 99%

Identification and treatment of symptoms associated with inflammation in medically ill patients

Dantzer

Capuron

Irwin

et al. 2008

Psychoneuroendocrinology

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Medically ill patients present with a high prevalence of non-specific comorbid symptoms including pain, sleep disorders, fatigue and cognitive and mood alterations that is a leading cause of disability. However, despite major advances in the understanding of the immune-to-brain communication pathways that underlie the pathophysiology of these symptoms in inflammatory conditions, little has been done to translate this newly acquired knowledge to the clinics and to identify appropriate therapies. In a multidisciplinary effort to address this problem, clinicians and basic scientists with expertise in areas of inflammation, psychiatry, neurosciences and psychoneuroimmunology were brought together in a specialized meeting organized in Bordeaux, France, on May 28-29, 2007. These experts considered key questions in the field, in particular those related to identification and quantification of the predominant symptoms associated with inflammation, definition of systemic and central markers of inflammation, possible domains of intervention for controlling inflammation associated symptoms, and relevance of animal models of inflammation associated symptoms. This

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BIOLOGICAL VARIATION OF INTERLEUKIN 6 (IL-6) AND SOLUBLE INTERLEUKIN 2 RECEPTOR (sIL2R) IN SERUM OF HEALTHY INDIVIDUALS

Cited by 44 publications

References 5 publications

Inflammatory Mediators and Cell Adhesion Molecules as Indicators of Severity of Atherosclerosis

Inflammatory Mediators and Cell Adhesion Molecules as Indicators of Severity of Atherosclerosis

Plasma and Cerebrospinal Fluid Interleukin-6 Concentrations in Posttraumatic Stress Disorder

Identification and treatment of symptoms associated with inflammation in medically ill patients

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