Biological toxicity risk assessment of two potential neutral carbon diesel fuel substitutes

Arias, Silvana; Estrada, Verónica; Ortiz, I.; Perez, Francisco José Molina; Agudelo, John R.

doi:10.1016/j.envpol.2022.119677

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…BEAS-2B cells did not show any toxic effects after exposure to extracts from biodiesel exhaust particles, and levels of IL-6 and IL-8 protein secretion did not change [206]. Similarly, HepG2 cell lines did not exhibit cytotoxic after exposure to soluble organics extracted from exhaust particles of three fuels (ULSD, ULSD+13% HVO, ULSD+20% HVO) [211]. Some studies have found that biodiesel is less toxic than diesel.…”

Section: Lower Toxicity Than Dieselmentioning

confidence: 86%

“…Compared to the control group, ROS production decreased, CYP1A1 gene expression was upregulated, and histone phosphorylation was not significantly increased in two cell cultures, i.e., double-stranded DNA damage was not evident [226]. Arias et al reported that soluble organic fractions (SOFs) extracted from PM produced by two fuels (ULSD, ULSD+13% butanol) had no cytotoxic activity against HepG2 cells and produced genotoxic reactions at the same level [211].…”

Section: Exposure Of Respiratory System Cell Linesmentioning

confidence: 99%

“…Monoculture cell lines commonly used in respiratory toxicity studies include human nasal epithelial cells (HNECs), human bronchial epithelial cell lines (HBECs) (e.g., BEAS-2B, HBEC3KT, 16-HBE, NL-20), human alveolar basal epithelial cells (e.g., A549, NCI-H441, HPAEpiC), human lung adenocarcinoma cell line (CALU-3), and mouse lung fibroblast cell line (L929) [191,[251][252][253][254][255]. Cell models commonly used in other human toxicity studies are the human epidermal carcinoma cell line (A431), normal human keratinocytes (NHKs), the human hepatocellular carcinoma cell line (HepG2), mouse macrophages (RAW264.7), the human lymphoblastoid cell line (MCL-5), the human monocytic cell line (U937, THP-1) and monocyte-derived macrophages (MDM), vascular endothelial cells (VECs), human pulmonary artery endothelial cells (HPAECs), human embryonic kidney cells (HEK 293T), and the pheochromocytoma line (PC12) [208,211,254,[256][257][258][259][260][261]. Although the monoculture system under immersion conditions is easy to operate and low in cost, it cannot reflect the actual in vivo cell-cell interaction, cannot truly simulate the exposure process, and is difficult to expose cells to gaseous or vaporized exhaust pollutants [262,263].…”

Section: Biological Modelsmentioning

confidence: 99%

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Zero-Carbon and Carbon-Neutral Fuels: A Review of Combustion Products and Cytotoxicity

Jin,

Li,

et al. 2023

Energies

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The use of zero-carbon and carbon-neutral fuels reduces emissions of conventional pollutants, but their emissions can be toxic and have various adverse effects on human health. This article reviews the possible combustion products of zero-carbon and carbon-neutral fuels, as well as their cytotoxic effects and potential health risks. At the same time, the review outlines biological models and toxicity detection methods commonly used in pollutant toxicity studies. Metals, nitrogen oxides (NOX), and ammonia (NH3) emitted from the combustion of metal fuels, hydrogen fuels, and ammonia fuels in zero-carbon fuels are harmful to human health. Exhaust emissions from carbon-neutral fuels, particularly biodiesel, and their blends with gasoline/diesel are cytotoxic, leading to severe cellular damage, such as oxidative damage, inflammatory responses, DNA damage, cell death, or apoptosis. Moreover, the normal function of the human body’s respiratory, cardiovascular, immune, digestive, urinary, and nervous systems may also be impacted by these fuel emissions according to cytotoxic research. Cytotoxicity of fuel combustion products is usually related to the fuel type, time, dose, and cell line used in the experiment. This review provides some ideas for the exhaust emission management of zero-carbon and carbon-neutral fuels and human health assessment. It also presents a theoretical and experimental basis for further research, including in vivo experiments.

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Section: Lower Toxicity Than Dieselmentioning

confidence: 86%

Section: Exposure Of Respiratory System Cell Linesmentioning

confidence: 99%