Biological toxicity effects of florfenicol on antioxidant, immunity and intestinal flora of zebrafish (Danio rerio)

Yun, Xiao; Zhou, Jie; Wang, Jiting; Li, Qi; Wang, Yanji; Zhang, Wenjing; Fan, Zhicheng

doi:10.1016/j.ecoenv.2023.115520

Cited by 12 publications

(9 citation statements)

References 48 publications

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“…The domestication and breeding methods of zebrafish were based on the methods of Yun Xiao et al 13 . In the feeding experiment, to prevent the impact of other pollutants on this experiment, it is necessary to clean up excrement in a timely manner and replace the exposed liquid every 48 h to ensure a constant concentration of SMX in the water.…”

Section: Methodsmentioning

confidence: 99%

Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)

Zhou,

Yun,

Wang

et al. 2024

Sci Rep

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This study evaluated the impacts of sulfamethoxazole (SMX) on antioxidant, immune, histopathological dynamic changes, and gut microbiota of zebrafish. SMX was carried out five groups: 0 (C), 3 mg/L (T3), 6 mg/L (T6), 12 mg/L (T12), and 24 mg/L (T24), with 5 replicates per group for an 8-weeks chronic toxicity test. It was found that SMX is considered to have low toxicity to adult zebrafish. SMX with the concentration not higher than 24 mg/L has no obvious inhibitory effect on the growth of fish. Under different concentrations of SMX stress, oxidative damage and immune system disorder were caused to the liver and gill, with the 12 and 24 mg/L concentration being the most significant. At the same time, it also causes varying degrees of pathological changes in both intestinal and liver tissues. As the concentration of SMX increases, the composition and abundance of the gut microbiota in zebrafish significantly decrease.

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Section: Methodsmentioning

confidence: 99%

Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)

Zhou,

Yun,

Wang

et al. 2024

Sci Rep

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“…Speci c primers for genes were designed based on the relevant cDNA sequences of zebra sh (Table 1). The speci c process and analysis method can be found in the reported of Yun et al (2023) 13 .…”

Section: Qrt-pcr Analysis Of Genes In Liver and Gillmentioning

confidence: 99%

“…(2023) 13 . In the feeding experiment, it is necessary to clean up excrement in a timely manner and replace the exposed liquid every 48 hours to ensure a constant concentration of microplastics in the water.…”

Section: Test Designmentioning

confidence: 99%

“…Take the entire gut of zebra sh, extract the contents, and perform total DNA extraction, PCR ampli cation, and sequencing of gut microbiota. The speci c process and analysis method can be found in the reported of Yun et al (2023) 13 .…”

Section: Analysis Of Gut Microbiotamentioning

confidence: 99%

“…The pre-treatment method for muscle samples is based on the method of Yun et al (2023) 13 . The analysis of SMX was conducted at Shandong Shitong Testing and Evaluation Technology Service Co., Ltd.…”

Section: Sulfamethoxazole Residue Analysismentioning

confidence: 99%

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Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)

Zhou,

Yun,

Wang

et al. 2023

Preprint

Self Cite

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The pollution of antibiotics in the water has also become a hot topic in recent years, especially the pollution of sulfonamide antibiotics, which seriously affects the development and growth of aquatic organisms. This study evaluated the impacts of sulfamethoxazole (SMX) on antioxidant, immune, histopathological dynamic changes, and gut microbiota of zebrafish. SMX was carried out five groups: 0 (C), 3 mg/L (T3), 6 mg/L (T6), 12 mg/L (T12), and 24 mg/L (T24), with 5 replicates per group for an 8-weeks chronic toxicity test. It was found that SMX is considered to have low toxicity to adult zebrafish. SMX with the concentration not higher than 24 mg/L has no obvious inhibitory effect on the growth of fish. Under different concentrations of SMX stress, oxidative damage and immune system disorder were caused to the liver and gill, with the 12 and 24 mg/L concentration being the most significant. At the same time, it also causes varying degrees of pathological changes in both intestinal and liver tissues. As the concentration of SMX increases, the composition and abundance of the gut microbiota in zebrafish significantly decrease.

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Acute/chronic triclosan exposure induces downregulation of m6A-RNA methylation modification via mettl3 suppression and elicits developmental and immune toxicity to zebrafish

Qian,

Pu,

et al. 2024

Chemosphere

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Biological toxicity effects of florfenicol on antioxidant, immunity and intestinal flora of zebrafish (Danio rerio)

Cited by 12 publications

References 48 publications

Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)

Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)

Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)

Acute/chronic triclosan exposure induces downregulation of m6A-RNA methylation modification via mettl3 suppression and elicits developmental and immune toxicity to zebrafish

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