Biological Therapy Using Propolis as Nutritional Supplement in Cancer Treatment

Galvão, Juliana Martins; Abreu, José A. da Silva; Cruz, Tonatiuh Alejandro; ., G.A.S. Machado; ., P. Niraldo; Daugsch, Andreas; Moraes, Cleber Silveira; Fořt, Petr

doi:10.3923/ijcr.2007.43.53

Cited by 16 publications

(4 citation statements)

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“…Other components presented in green propolis might be involved in anti-inflammatory effects observed on its results. Propolis, to produce the anti-inflammatory effect, acts in the modulation of cytokines and inflammatory enzymes, such as the suppression of the production of prostaglandins, leukotrienes, histamine, and TGF- β 1 [ 26 , 27 ]. Reducing the number of microorganisms in dental plaque results in the reduction of products released by them, which act as trigger of gingival inflammation.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evidence of the Efficacy of a Mouthwash ContainingPropolis for the Control of Plaque and Gingivitis: A Phase II Study

Pereira

Silva

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to evidence the clinical efficacy of an alcohol-free mouthwash containing 5.0% (W/V) Brazilian green propolis (MGP 5%) for the control of plaque and gingivitis. Twenty five subjects, men and women aging between 18 and 60 years old (35 ± 9), were included in a clinical trials phase II study who had a minimum of 20 sound natural teeth, a mean plaque index of at least 1.5 (PI), and a mean gingival index of at least 1.0 (GI). They were instructed to rinse with 10 mL of mouthwash test for 1 minute, immediately after brushing in the morning and at night. After 45 and 90 days using mouthwash, the results showed a significant reduction in plaque and in gingival index when compared to samples obtained in baseline. These reductions were at 24% and 40%, respectively (P < .5). There were no important side effects in soft and hard tissues of the mouth. In this study, the MGP 5% showed evidence of its efficacy in reducing PI and GI. However, it is necessary to perform a clinical trial, double-blind, randomized to validate such effectiveness.

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Section: Discussionmentioning

confidence: 99%

Clinical Evidence of the Efficacy of a Mouthwash ContainingPropolis for the Control of Plaque and Gingivitis: A Phase II Study

Pereira

Silva

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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“…It has been reported that propolis may enhance the radiosensitivity of breast cancer cells by interfering with RNR function [14]. Another research group suggested that propolis is an effective food supplement and should be used by people in cancer treatment to improve their quality of life [18]. Propolis is natural compounds from bee wax with bioactive enzymes, terpenes, antioxidant flavonoids, phenolic acid, and phenolic compounds.…”

Section: Discussionmentioning

confidence: 99%

Antitumor activity of withaferin-A and propolis in benz (a) pyrene-induced breast cancer

Muninathan¹

2022

Bioinformation

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Female breast cancer is the leading malignancy surpassing lung cancer recently, and its incidence is continued to rise in many countries. The existing anticancer drugs have limitations like drug resistance and adverse effects leading to poor clinical outcomes. The natural compounds withaferin-A and propolis have been individually reported for their anticancer activity in preclinical models. However, the combined effect of these compounds has not been studied especially in breast cancer models. Therefore, it is of interest to evaluate the effect of Withaferin-A and propolis on Benz(a)pyrene-induced breast cancer. Wistar rats of female gender were treated with saline (normal control), Benz(a)pyrene (disease control), Benz(a)pyrene+ Withaferin-A or Propolis, Benz(a)pyrene+ Withaferin-A+ Propolis. At the end of the treatment, the plasma levels of carcino embryonic antigen (CEA) were measured. We observed a decrease in carcino embryonic antigen (CEA) levels in rats received withaferin-A and propolis combination rather than individual compounds indicating their beneficial role in breast cancer. Results of the present study show that propolis, when combined with withaferin A, exhibits better anti tumor activity than its individual effect in Benz (a) pyrene-induced mammary carcinogenesis.

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“…Synergistic effects of different compounds seem to be the most important process to explain the antibacterial activity of propolis, since it is well established that a single propolis component does not have an activity greater than the other components of propolis isolated [ 38 ]. As previously mentioned, propolis, to produce the anti-inflammatory effect, acts in the modulation of cytokines and inflammatory enzymes, such as the suppression of the production of prostaglandins, leukotrienes, and histamine [ 45 , 46 ]. Therefore, a reduction in the number of microorganisms in dental plaque results in the reduction of products released by them, which act as trigger of gingival inflammation, reducing the severity of plaque [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth Extraction in Periodontal Disease

Lisbona-González

Muñoz-Soto

Lisbona-González

et al. 2021

Plants

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This study investigated the antimicrobial effects of a mouthwash containing propolis and the effect of a propolis paste formulation on dental healing after teeth extraction in patients with periodontal disease. In the mouthwash experience, the population comprised 40 patients, which were divided as follows: the control mouthwash, 0.2% chlorhexidine (v/v) mouthwash, 2% (w/v) propolis mouthwash, and propolis + chlorhexidine mouthwash. The study of the propolis paste comprised a population of 60 patients with periodontal disease, and a total of 120 symmetric tooth extractions were performed. Propolis showed antimicrobial activity by itself, and especially with the chlorhexidine association. Three days after surgery in the teeth treated with control paste, only 13.4% had completely healed; however, with propolis paste, in 90% of the periodontal sockets, healing was complete. In addition, a reduction in Mutans Streptococci and Lactobacilli cfu was observed with propolis, and especially with the association of chlorhexidine + propolis. Propolis mouthwash reduced bacterial proliferation, especially in association with chlorhexidine. Propolis paste is a viable alternative for socket healing after dental extraction. The knowledge gained from these findings will provide a foundation for similar propolis therapies in order to improve the healing process after dental surgery.

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Biological Therapy Using Propolis as Nutritional Supplement in Cancer Treatment

Cited by 16 publications

References 0 publications

Clinical Evidence of the Efficacy of a Mouthwash ContainingPropolis for the Control of Plaque and Gingivitis: A Phase II Study

Clinical Evidence of the Efficacy of a Mouthwash ContainingPropolis for the Control of Plaque and Gingivitis: A Phase II Study

Antitumor activity of withaferin-A and propolis in benz (a) pyrene-induced breast cancer

Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth Extraction in Periodontal Disease

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