Biological therapy: approaches in colorectal cancer

Zbar, A. P.; Lemoine, N. R.; Wadhwa, Meenu; Thomas, Huw; Snary, David; Kmiot, WA

doi:10.1038/bjc.1998.114

Cited by 17 publications

(4 citation statements)

References 121 publications

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“…Recombinant carcinoembryonic antigen expressed in vaccinia virus has induced CTL responses against allogeneic, HLAmatched CRC cells in CRC patients. 32 Recombinant adenovirus expressing gp100 occasionally has induced CTL responses in melanoma patients. 33 This low response rate has been attributed to preexisting immunity to wild-type adenovirus in the pa-tients, which may have contributed to enhanced clearance of the recombinant virus from the patients' body fluids and tissues.…”

Section: Introductionmentioning

confidence: 99%

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Colorectal Cancer Vaccines: Antiidiotypic Antibody, Recombinant Protein, and Viral Vector

Basak

Eck

Gutzmer

et al. 2000

Annals of the New York Academy of Sciences

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The colorectal cancer antigen GA733 (also termed CO17‐1A, KSI‐4, Ep‐CAM, KSA) has proved to be a useful target in passive immunotherapy with monoclonal antibody and in active immunotherapy with antiidiotypic antibodies in cancer patients. The GA733 antigen was molecularly cloned and expressed in baculovirus (BV), adenovirus (AV), and vaccinia virus (VV). Recombinant BV‐, VV‐, and AV‐GA733 induced antigen‐specific cytotoxic antibodies and proliferative and delayed‐type hypersensitive lymphocytes. However, only the AV recombinant induced antigen‐specific cytolytic T lymphocytes and regression of established tumors. Cured mice were protected against challenge with antigen‐negative tumors, indicating antigen spreading of immune responses. In a model of active immunotherapy against the murine homologue of the human GA733 antigen, murine epithelial glycoprotein (mEGP), BV‐derived mEGP protein in various adjuvants did not protect mice against a challenge with mEGP‐positive tumors. AV mEGP, only when combined with interleukin‐2, significantly inhibited growth of established mEGP‐positive tumors. This is in contrast to the same vaccine expressing the human antigen that was effective without interleukin‐2. AV GA733, in combination with interleukin‐2, is a candidate vaccine for colorectal cancer patients.

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Section: Introductionmentioning

confidence: 99%

“…Recombinant cancer Ag vaccines have many potential advantages over other vaccines. Recombinant carcinoembryonic antigen expressed in vaccinia virus has induced CTL responses against allogeneic, HLA‐matched CRC cells in CRC patients 32. Recombinant adenovirus expressing gp100 occasionally has induced CTL responses in melanoma patients 33.…”

Section: Introductionmentioning

confidence: 99%

Colorectal Cancer Vaccines: Antiidiotypic Antibody, Recombinant Protein, and Viral Vector

Basak

Eck

Gutzmer

et al. 2000

Annals of the New York Academy of Sciences

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“…2 The gastro-intestinal carcinomaassociated antigen GA733 3 (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM 4 -7 ) is a suitable target for passive and active specific immunotherapy against gastro-intestinal tumors. 2 The gastro-intestinal carcinomaassociated antigen GA733 3 (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM 4 -7 ) is a suitable target for passive and active specific immunotherapy against gastro-intestinal tumors.…”

mentioning

confidence: 99%

“…Responses were observed both before and after therapy, with no change (n.c.), an increase (1) or a decrease(2) in the response after therapy. NED, no evidence of disease.…”

mentioning

confidence: 99%

Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients

et al. 2001

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Transfection of ?(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells

et al. 2000

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Sialyl Lewis x and sialyl Lewis a are oncodevelopmental antigens involved in the pathogenesis of colon adenocarcinoma. Biosynthesis of these glycans is controlled by alpha(1,3/1,4)fucosyltransferases. We report the disruption of sialyl Lewis x/a biosynthesis and inhibition of colon carcinoma cell proliferation by stable transfection of antisense sequences directed at the human Lewis alpha(1,3/1,4)fucosyltransferase gene, FUT3, and the plasma alpha(1,3)fucosyltransferase gene, FUT6. COLO-205 cells expressed high levels of sialyl Lewis x/a, alpha(1,3)fucosyltransferase activity, and FUT3/6 transcripts, but COLO

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Biological therapy: approaches in colorectal cancer

Cited by 17 publications

References 121 publications

Colorectal Cancer Vaccines: Antiidiotypic Antibody, Recombinant Protein, and Viral Vector

Colorectal Cancer Vaccines: Antiidiotypic Antibody, Recombinant Protein, and Viral Vector

Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients

Transfection of ?(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells

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