Biological Therapies in Orthopedics and Sports Medicine

Samitier, Gonzalo; Alentorn-Geli, Eduard; Filardo, Giuseppe; Aicale, Rocco; Tarulli, Filippo Rosati; Maffulli, Nicola; Tramś, Ewa; Kaminska, Katarzyna-Kozar; Pomianowski, Stanisław; Kaminski, Rafal; Sánchez, Mikel; Delgado, Diego; Garate, Ane; Sánchez, Pello; Bilbao, Ane Miren; Fiz, Nicolás; Dallo, Ignacio; Kumar, Vetri; Gobbi, Alberto; Cugat, Ramón

doi:10.1007/978-3-662-61264-4_28

Cited by 2 publications

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“…Lecture Book featuring a chapter on Biological Therapies in Orthopedics and Sports Medicine [7]. This emphasizes the fact that there is high interest in biologically augmented meniscus repair.…”

Section: Nonetheless Esska Published An Instructional Coursementioning

confidence: 99%

A Combination of Tisseel Fibrin Glue and Orthokine ACS improves Knee Meniscus Injury Treatment and helps Avoid Surgery 4-year follow-up Archive Study

2021

Sports Injr Med

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Background:The routine use of biological therapies with potentially regenerative augmentation of tissue repair is reality. Techniques applied include stem cells, platelet preparations, recombinant growth factors and autologous conditioned serum (ACS), partly in combination with other techniques such as matrices, surgery and fibrin glue. ACS contains blood cell released factors which have the potential to improve tissue repair or regeneration.Aim: Retrospective analysis of clinical data of intra-articular fibrin glue fixation combined with ACS injections in clinical cases of routine outpatients presenting with knee pain and MRI-confirmed meniscal defects.Methods: An established intra-articular injection treatment method for osteoarthritis involving autologous conditioned serum (ACS) was routinely employed. ACS is prepared from patient's blood subjected to extended coagulation at physiologic temperature. The serum supernatant is separated from cellular components by centrifugation. A dedicated medical device (EOT ® II, Orthokine) is employed. Outpatients (n = 170), with lesions of the knee meniscus of heterogeneous genesis, severity and duration, were treated with fibrin glue to fixate the tissue injury followed by weekly intra-articular ACS injections (up to 6). Average age was 55.29 years (SD ±12.48) (range 14-84). Follow ups extend from baseline up to 4 years. Clinical effects are documented by WOMAC score at baseline, 6 weeks and yearly intervals. All analyses were performed from archived patient files.Results: 8 of 170 patients chose surgical treatment of the meniscal injury. 162 patients avoided surgery during the period analyzed. Mean WOMAC global score improved from 34.62 (SD ± 18.48) to 13.18 (SD ± 9.52) (p = 0.0015) at 4 years. Conclusion:This archive evaluation of a heterogeneous real-life cohort suggests that intra-articular fixation of meniscus injuries with fibrin glue followed by 4 i.a. ACS/BCS injections improves knee symptoms associated with meniscal injury. Controlled studies of Fibrin Glue + ACS treatment for meniscal lesions are advocated.

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Section: Nonetheless Esska Published An Instructional Coursementioning

confidence: 99%