Biological therapies for spondyloarthritis

Bruner, Vincenzo; Atteno, Mariangela; Spanò, Angelo; Scarpa, Raffaele; Peluso, Rosario

doi:10.1177/1759720x14535512

Cited by 22 publications

(11 citation statements)

References 89 publications

(90 reference statements)

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“…Therefore, it seems that this common pathway arises from diverse sets of genes in distinct tissues. TNF has a pivotal role in response to infections and in the pathogenesis of different immune-mediated disorders, like rheumatoid arthritis (RA) and spondyloarthritis (SpA) [35, 36]. However, its role in fibrotic disorders like SSc is controversial [37].…”

Section: Discussionmentioning

confidence: 99%

Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis

et al. 2019

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Background: Systemic sclerosis (SSc), a multi-organ disorder, is characterized by vascular abnormalities, dysregulation of the immune system, and fibrosis. The mechanisms underlying tissue pathology in SSc have not been entirely understood. This study intended to investigate the common and tissue-specific pathways involved in different tissues of SSc patients. Methods: An integrative gene expression analysis of ten independent microarray datasets of three tissues was conducted to identify differentially expressed genes (DEGs). DEGs were mapped to the search tool for retrieval of interacting genes (STRING) to acquire protein-protein interaction (PPI) networks. Then, functional clusters in PPI networks were determined. Enrichr, a gene list enrichment analysis tool, was utilized for the functional enrichment of clusters. Results: A total of 12, 2, and 4 functional clusters from 619, 52, and 119 DEGs were determined in the lung, peripheral blood mononuclear cell (PBMC), and skin tissues, respectively. Analysis revealed that the tumor necrosis factor (TNF) signaling pathway was enriched significantly in the three investigated tissues as a common pathway. In addition, clusters associated with inflammation and immunity were common in the three investigated tissues. However, clusters related to the fibrosis process were common in lung and skin tissues. Conclusions: Analysis indicated that there were common pathological clusters that contributed to the pathogenesis of SSc in different tissues. Moreover, it seems that the common pathways in distinct tissues stem from a diverse set of genes.

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Section: Discussionmentioning

confidence: 99%

Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis

et al. 2019

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“…In the past two decades, there have been many new developments in the treatment of SpA, such as the use of biologic drugs in severe cases (reviewed by Bruner et al) [16]. The use of these biological agents (e.g., tumour necrosis factor- (TNF-) alpha blockers like infliximab, adalimumab, and etanercept) has brought revolutionary changes in the management of the disease.…”

Section: Spondyloarthritismentioning

confidence: 99%

Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

Wong

2019

Advances in Pharmacological Sciences

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Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Research has shown that other than pain relief, NSAIDs have disease-modifying effects in SpA. However, to achieve these effects, continuous and/or long-term NSAID use is usually required. This review will give an overview of SpA, discuss NSAIDs and their disease-modifying effects in SpA, and highlight some of the important adverse effects of long-term and continuous NSAID use, particularly those related to the gastrointestinal, renal, and cardiovascular systems.

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“…Although there is no alternative option available if TNF-α inhibitors are not effective, other biological agents such as inhibitors of inflammatory cytokines (e.g., interleukin [IL]-1 and IL-6) have been actively investigated 21) .…”

Section: Dignosis and Medical Management Of Ankylosing Spondylitismentioning

confidence: 99%

Medical Treatment of Ankylosing Spondylitis

Moon

Kim

2014

Hip & Pelvis

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The diagnosis of ankylosing spondylitis is often delayed due to ambiguous clinical manifestations and strict diagnostic criteria. However, imaging techniques such as magnetic resonance imaging have been found effective for the early diagnosis of non-radiographic sacroiliitis. New tumor necrosis factor alpha (TNF-α) inhibitors have good efficacy for patients with persistently high disease activity despite conventional nonsteroidal anti-inflammatory drug treatment. Thus, early diagnosis and aggressive treatments are essential for ankylosing spondylitis patients. Because many patients complain of musculoskeletal pains, especially around the sacroiliac joint area, hip specialists should be informed of up-to-date knowledge. In this review, we discuss new diagnostic criteria for ankylosing spondylitis, administration methods of TNF-α inhibitors, and the long-term follow-up results for patients treated with TNF-α inhibitors.

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Biological therapies for spondyloarthritis

Cited by 22 publications

References 89 publications

Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis

Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis

Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

Medical Treatment of Ankylosing Spondylitis

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