Biological Studies, Synthesis and Spectral Characterization of Nitrogen Donor Macrocyclic Co(II) Complexes

Abstract

New Co(II) complexes with macrocyclic ligands 2, 7, 9, 14-tetrahydroxy phenyl-1, 3, 6, 8, 10, 13-hexaazacyclooctadecane (L 1 ), 2, 7, 9, 14-tetracyclohexane-1, 3, 6, 8, 10, 13-hexaazacyclo octadecane(L 2 ) have been synthesized by template method. The structure of complexes was determined by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, IR and electronic spectral studies. Based on the analytical analysis i.e. molar conductance the complexes were found to be non-electrolytic in nature except the complexes [Co(L . Magnetic moment and the electronic spectra of the complexes suggest that the ligands coordinate to metal ion via four donor sites to give six coordinate complexes having octahedral geometry except [Co(L 1,2 )] (NO 3 ) 2 ] which is four coordinated tetrahedral geometry. Food Poison Technique was employed for screening the in vitro antifungal studies of the complexes. The complexes were also examined for antifungal studies against pathogenic strains like Alternaria brassicae, Fusarium moniliformae, Rhizoctonia solani.