Biological studies of AT-308

Imai, Yumiko; Shimamoto, Kiro

doi:10.1016/0021-9150(73)90140-8

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1975

1981

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Cited by 8 publications

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“…in rats maintained on normal diets and the other hypocholesterolemic agents have also been introduced into clinical use. From the studies (3)(4)(5) According to the procedure of Harris (8) and Barber(9) , p-hydroxybenzo-[ 14C]nitrile (111) was synthesized from p-bromophenol and cuprous [ 14C] cyanide (11) which prepared by reacting K14CN with CuSOq in the presence of NaHSO-, as shown in the reaction scheme. p-Hydroxy-[ a~nidoxime-~~C] benzamidoxime (IV) obtained in 81% yield from I11 was reacted with nicotinoyl chloride to afford 3-(4- added to 360 mg of I11 in 1 ml of ethanol and the mixture was heated at 65-70" for 5 h with stirring.…”

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confidence: 99%