Biological stress responses in high and low trait anxious students

Davis, Denise D.; Dunlop, Stephen R.; Shea, Philip A.; Brittain, Harry; Hendrie, Hugh C.

doi:10.1016/0006-3223(85)90209-4

Cited by 23 publications

(12 citation statements)

References 14 publications

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“…In humans similar data have been reported [24,25]. We also assayed whole-blood serotonin level, which mainly re flects platelet serotonin, as a marker o f the degree of stress.…”

Section: Discussionsupporting

confidence: 64%

Time-Dependent Changes in Platelet Aggregation, Fibrinolytic Activity, and Peripheral Serotonergic Measures in Rats Subjected to Water Immersion Restraint Stress

Małyszko¹,

Urano²,

Takada³

et al. 1994

Pathophysiol Haemos Thromb

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The effects of water immersion restraint stress on collagen-induced platelet aggregation in whole blood, and on the fibrinolytic and serotonergic systems in rats have been studied. One hour long stress caused a release of tissue plasminogen activator (tPA) into the blood and a shortening of euglobulin clot lysis time (ECLT), whereas restraint of longer duration was responsible for a reduction in platelet aggregation, an elevation in the activity of plasminogen activator inhibitor with a concomitant fall in tPA and a prolongation of ECLT relative to controls. Whole-blood and plasma serotonin and its metabolite 5-hydroxyindoleacetic acid were also higher in the stressed rats and whole-blood serotonin level showed a negative correlation with tPA in the stressed rats. Either stress and/ or its duration are responsible for changes in both fibrinolytic and serotonergic systems.

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“…In humans similar data have been reported [24,25]. We also assayed whole-blood serotonin level, which mainly re flects platelet serotonin, as a marker o f the degree of stress.…”

Section: Discussionsupporting

confidence: 64%

Time-Dependent Changes in Platelet Aggregation, Fibrinolytic Activity, and Peripheral Serotonergic Measures in Rats Subjected to Water Immersion Restraint Stress

Małyszko¹,

Urano²,

Takada³

et al. 1994

Pathophysiol Haemos Thromb

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“…Survey studies have demonstrated a significant association between daily caffeine intake and anxiety among people with panic disorder 255 , 256 or high trait anxiety when under stress. 263 However, another study reported no association between daily caffeine intake and anxiety. 264 There have been no controlled studies of the long‐term effects of caffeine in patients with anxiety disorder.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of complementary and self‐help treatments for anxiety disorders

Jorm

Christensen

Griffiths

et al. 2004

Medical Journal of Australia

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Objectives: To review the evidence for the effectiveness of complementary and self‐help treatments for anxiety disorders. Data sources: Systematic literature search using PubMed, PsycLit, and the Cochrane Library. Data synthesis: 108 treatments were identified and grouped under the categories of medicines and homoeopathic remedies, physical treatments, lifestyle, and dietary changes. We give a description of the 34 treatments (for which evidence was found in the literature searched), the rationale behind the treatments, a review of studies on effectiveness, and the level of evidence for the effectiveness studies. Conclusions: The treatments with the best evidence of effectiveness are kava (for generalised anxiety), exercise (for generalised anxiety), relaxation training (for generalised anxiety, panic disorder, dental phobia and test anxiety) and bibliotherapy (for specific phobias). There is more limited evidence to support the effectiveness of acupuncture, music, autogenic training and meditation for generalised anxiety; for inositol in the treatment of panic disorder and obsessive‐compulsive disorder; and for alcohol avoidance by people with alcohol‐use disorders to reduce a range of anxiety disorders.

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“…For example, B max values of 125 I-lysergic acid diethylamide binding to platelets were significantly and inversely correlated to HA scores [50], whereas platelet imipramine binding was not related to HA in another study [51]. Examination stress has been reported to be associated with higher peripheral levels of 5-HT in subjects scoring high on anxiety [52] and performance was found to be reduced after treatment with fluoxetine in high anxiety subjects [53].…”

Section: Introductionmentioning

confidence: 92%

Endocrine Responses after <i>d</i>-Fenfluramineand Ipsapirone Challenge: Further Support for Cloninger’s Tridimensional Model of Personality

et al. 2000

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The tridemensional model of personality introduced by Cloninger relates aspects of novelty seeking to the dopaminergic, harm avoidance (HA) to the serotonergic, and reward dependence to the noradrenergic neurotransmitter system. Using a neuroendocrine challenge paradigm, this study investigates whether subjects characterized by blunted cortisol (CORT) responses after ipsapirone (IPS) relate to different subfactors of HA from those characterized by blunted prolactin (PRL) responses after treatment with d-fenfluramine (D-FEN). Moreover, subjects blunted in both responses should differ in scale values of subfactors of HA from those with only one or no blunted reactions. In the first part of the experiment, 16 healthy male volunteers were treated with 15 mg D-FEN. The second part of the study (about 1 year later) consists of a challenge with the partial 5-hydroxytryptamine-1a (5-HT_1a) agonist IPS (10 mg) in the same subjects. The results indicate that blunted PRL responses are accompanied by high values in HA, while the main effect of IPS responsivity did not relate significantly to this dimension. With respect to the subscales of HA, subjects blunted in both responses (PRL–/C–) exhibit significantly higher levels in fatigability and asthenia when compared to all other groups (PRL–/C+, PRL+/C–,PRL+/C+). The data demonstrate that combined challenge tests may shed more light on the biological basis of personality and that HA and most clearly fatigability and asthenia relate to the 5-HT system.

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Biological stress responses in high and low trait anxious students

Cited by 23 publications

References 14 publications

Time-Dependent Changes in Platelet Aggregation, Fibrinolytic Activity, and Peripheral Serotonergic Measures in Rats Subjected to Water Immersion Restraint Stress

Time-Dependent Changes in Platelet Aggregation, Fibrinolytic Activity, and Peripheral Serotonergic Measures in Rats Subjected to Water Immersion Restraint Stress

Effectiveness of complementary and self‐help treatments for anxiety disorders

Endocrine Responses after <i>d</i>-Fenfluramineand Ipsapirone Challenge: Further Support for Cloninger’s Tridimensional Model of Personality

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