Biological Significance of Hetero-Scaffolds Based Gold(III) Complexes

Kanthecha, Darshana N.; Raval, Dilip B.; Thakkar, Vasudev R.; Patel, Mohan N.

doi:10.17344/acsi.2017.4018

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…DNA extraction has been carried out from S. pombe cells for the study of DNA cleavage by agarose gel electrophoresis [21]. The result shows the effects of the compound on the integrity of DNA.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes

Kanthecha

Bhatt

Patel

2019

Heliyon

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Five imidazo [1,2- a ]pyridine derivatives and their Au(III) complexes were synthesized. The compounds were characterized by 1 H-NMR, 13 C-NMR, IR, mass, UV-visible, elemental analysis, conductivity and magnetic measurement studies. All the compounds were screened for diverse biological activities to check the effect of coordination of Au(III) with imidazo [1,2- a ]pyridine heterocycles. The DNA interaction ability of compounds were studied as the change in absorption maxima and position of HS-DNA in presence of compounds and viscosity measurement due to change in DNA length under the influence of compounds. The computational insight of compound-DNA interaction was taken in docking study. All the results suggest intercalation mode of binding. The cellular level cytotoxic nature of compounds was evaluated using trypan blue dye staining of dead cell in cell viability assay. The smearing of DNA was observed, while DNA extracted from S. pombe cells in presence of complexes was subjected to gel electrophoresis, which shows their toxic effect on DNA. The complexes were evaluated for cytotoxicity on human A549 (Lung adenocarcinoma) cell line by MTT assay (IC 50 values). The in vitro cytotoxicity in terms of LC 50 value was checked on a simple zoological organism, brine shrimp.

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Section: Resultsmentioning

confidence: 99%

Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes

Kanthecha

Bhatt

Patel

2019

Heliyon

Self Cite

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“…The LC 50 value was obtained from the antilogarithm of log 19 at 50% mortality (LC 50 ). All data were collected from three independent experiments 59 – 61 .…”

Section: Methodsmentioning

confidence: 99%

Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine

Pandya,

Socha,

Dubey

et al. 2023

Sci Rep

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A 3D-supramolecular nickel integrated Ni-SDZ complex was synthesized using sodium salt of sulfadiazine as the ligand and nickel(II) acetate as the metal salt using a condensation process and slow evaporation approach to growing the single crystal. The metal complex was characterized for its composition, functional groups, surface morphology as well as complex 3D structure, by resorting to various analytical techniques. The interacting surface and stability as well as reactivity of the complex were carried out using the DFT platform. From ADMET parameters, human Intestinal Absorbance data revealed that the compound has the potential to be well absorbed, and also Ni-SDZ complex cannot cross the blood–brain barrier (BBB). Additionally, the complex's DNA binding affinity and in-vivo and in-vitro cytotoxic studies were explored utilizing UV–Vis absorbance titration, viscosity measurements, and S. pombe cells and brine shrimp lethality tests. In visible light radiation, the Ni-SDZ complex displayed exceptional photo-degradation characteristics of approximately 70.19% within 70 min against methylene blue (MB).

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“…So, they might affect as antitumor reagents by preventing cell growth and division [3]. Therefore, examination of the DNA binding ability of the transition metal complexes is an important research topic [4,5].…”

Section: Introductionmentioning

confidence: 99%

Iron(III) Complexes Derived From Azo-Containing Salicylaldoxime Ligands: Synthesis, Structures and Biological Evaluations

Serbest¹,

Dural²,

Ayvaz³

et al. 2021

El-Cezeri Fen Ve Mühendislik Dergisi

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Two novel mononuclear Fe(III) complexes derived from azo-containing salicylaldoxime ligands were synthesized and characterized by elemental analyses, spectroscopic data i.e. IR, 1H NMR, UV-Vis, electrospray ionization mass spectra, molar conductivity, and magnetic susceptibility measurements. Both the experimental and theoretical results strongly suggest that the ligands have a major contribution to the azo enol imine form instead of the hydrazo keto imine and azo keto amine forms in solution/solid-state. The electronic spectra of the ligands and their iron(III) complexes were calculated theoretically for the band assignments by using DFT and TD-DFT/CPCM methods. DNA binding, cleavage, and antioxidative activities of the investigated compounds were studied. It has been shown that the ligands and their iron (III) complexes tested bind to DNA via the intercalative mode. It was observed that all molecules tested inhibited topoisomerase I almost to the same degree. One of the most striking results among the antioxidant activity tests is that the hydroxyl radical scavenging activities of the ligands and complexes are higher than the standard antioxidant mannitol.

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Biological Significance of Hetero-Scaffolds Based Gold(III) Complexes

Cited by 9 publications

References 43 publications

Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes

Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes

Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine

Iron(III) Complexes Derived From Azo-Containing Salicylaldoxime Ligands: Synthesis, Structures and Biological Evaluations

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