Biological SERS-active sensor platform based on flexible silk fibroin film and gold nanoislands

Choi, Ji Hyeon; Choi, Munsik; Ho, Tien Son; Kim, Soogeun; Choi, Sang‐Jun; Choi, Seung Ho; Byun, Kyung Min

doi:10.1364/oe.452665

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…The nano-islands offer a dense nano-gap structure and excellent spatial uniformity, resulting in sensitive detection. SERS intensity of nano-island was found to be 14 times that of the conventionally used smooth silicon surface, which also improves sensitivity and detection limit [79]. Liu et al reported a Ti 3 C 2 Tx Mxenes and AgNPs-based SERS label-free sensor based on an electrostatic self-assembly method to detect dopamine concentrations of 5-500 µM, as shown in Figure 9a.…”

Section: Sers Sensorsmentioning

confidence: 96%

Novel Wearable Optical Sensors for Vital Health Monitoring Systems—A Review

2023

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Wearable sensors are pioneering devices to monitor health issues that allow the constant monitoring of physical and biological parameters. The immunity towards electromagnetic interference, miniaturization, detection of nano-volumes, integration with fiber, high sensitivity, low cost, usable in harsh environments and corrosion-resistant have made optical wearable sensor an emerging sensing technology in the recent year. This review presents the progress made in the development of novel wearable optical sensors for vital health monitoring systems. The details of different substrates, sensing platforms, and biofluids used for the detection of target molecules are discussed in detail. Wearable technologies could increase the quality of health monitoring systems at a nominal cost and enable continuous and early disease diagnosis. Various optical sensing principles, including surface-enhanced Raman scattering, colorimetric, fluorescence, plasmonic, photoplethysmography, and interferometric-based sensors, are discussed in detail for health monitoring applications. The performance of optical wearable sensors utilizing two-dimensional materials is also discussed. Future challenges associated with the development of optical wearable sensors for point-of-care applications and clinical diagnosis have been thoroughly discussed.

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Section: Sers Sensorsmentioning

confidence: 96%

Novel Wearable Optical Sensors for Vital Health Monitoring Systems—A Review

2023

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“…Plasmonic structures should be placed on materials with a low Raman signal and should be resistant to the solvents employed to dissolve the test molecule. As depicted in Figure 7 , several materials were evaluated for this purpose in recent years, including graphene [ 88 ], nanowires [ 89 ], silk [ 90 ], paper [ 91 ], and flexible polymers [ 92 ], each of which adds diverse uses to the substrate. These materials enable the creation of SERS substrates that are inexpensive, and expandable for large-scale production.…”

Section: Sers Substrates For Diagnosis At the Point-of-carementioning

confidence: 99%

Miniaturized Raman Instruments for SERS-Based Point-of-Care Testing on Respiratory Viruses

et al. 2022

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As surface-enhanced Raman scattering (SERS) has been used to diagnose several respiratory viruses (e.g., influenza A virus subtypes such as H1N1 and the new coronavirus SARS-CoV-2), SERS is gaining popularity as a method for diagnosing viruses at the point-of-care. Although the prior and quick diagnosis of respiratory viruses is critical in the outbreak of infectious disease, ELISA, PCR, and RT-PCR have been used to detect respiratory viruses for pandemic control that are limited for point-of-care testing. SERS provides quantitative data with high specificity and sensitivity in a real-time, label-free, and multiplex manner recognizing molecular fingerprints. Recently, the design of Raman spectroscopy system was simplified from a complicated design to a small and easily accessible form that enables point-of-care testing. We review the optical design (e.g., laser wavelength/power and detectors) of commercialized and customized handheld Raman instruments. As respiratory viruses have prominent risk on the pandemic, we review the applications of handheld Raman devices for detecting respiratory viruses. By instrumentation and commercialization advancements, the advent of the portable SERS device creates a fast, accurate, practical, and cost-effective analytical method for virus detection, and would continue to attract more attention in point-of-care testing.

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“…[22] Fibroin is often discussed as substrate material for bioabsorbable electronics or an encapsulation to increase the biocompatibility of implantable devices. [22][23][24][25][26][27] A synthetic, commercially available alternative to fibroin depicts PLA, which is synthesized from starch (e.g., from corn, sugar cane, or potatoes). [28] A reasonable number of biomedical studies deal with PLA as material for medical applications, for example, for tissue engineering, drug carrier systems, cancer therapy, skin and tendon regeneration, orthopaedic and dental devices, surgical tools, and also as substrate material for (bio)sensors.…”

Section: Introductionmentioning

confidence: 99%

Transient magnesium‐based thin‐film temperature sensor on a flexible, bioabsorbable substrate for future medical applications

Janus,

Achtsnicht,

Drinic

et al. 2023

Applied Research

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In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium, and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin‐film magnesium‐based meander‐like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium‐based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue‐like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium‐based layers. The 3‐layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.

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Biological SERS-active sensor platform based on flexible silk fibroin film and gold nanoislands

Cited by 5 publications

References 39 publications

Novel Wearable Optical Sensors for Vital Health Monitoring Systems—A Review

Novel Wearable Optical Sensors for Vital Health Monitoring Systems—A Review

Miniaturized Raman Instruments for SERS-Based Point-of-Care Testing on Respiratory Viruses

Transient magnesium‐based thin‐film temperature sensor on a flexible, bioabsorbable substrate for future medical applications

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