Biological Safety Cabinets, Decontamination or Sterilization with Paraformaldehyde

Fink, Richard; Liberman, Daniel F.; Murphy, Kim; Lupo, David; Israeli, Eitan

doi:10.1202/0002-8894(1988)049<0277:bscdos>2.0.co;2

Cited by 2 publications

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“…Decontamination with aqueous and gaseous formaldehyde has been used for many years in laboratory, medical, and industrial settings (Sweet 1971;Fink et al 1988;Cross and Lach 1990;Lach 1990). On a large scale, formaldehyde was used to decontaminate Gruinard Island, Scotland, after the British military conducted explosives testing with Bacillus anthracis spores during World War II (Inglesby et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Formaldehyde gas inactivation ofBacillus anthracis,Bacillus subtilis, andGeobacillus stearothermophilusspores on indoor surface materials

Rogers

Choi

Richter

et al. 2007

Journal of Applied Microbiology

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Aims: To evaluate the decontamination of Bacillus anthracis, Bacillus subtilis, and Geobacillus stearothermophilus spores on indoor surface materials using formaldehyde gas. Methods and Results: B. anthracis, B. subtilis, and G. stearothermophilus spores were dried on seven types of indoor surfaces and exposed to approx. 1100 ppm formaldehyde gas for 10 h. Formaldehyde exposure significantly decreased viable B. anthracis, B. subtilis, and G. stearothermophilus spores on all test materials. Significant differences were observed when comparing the reduction in viable spores of B. anthracis with B. subtilis (galvanized metal and painted wallboard paper) and G. stearothermophilus (industrial carpet and painted wallboard paper). Formaldehyde gas inactivated ≥50% of the biological indicators and spore strips (approx. 1 × 106 CFU) when analyzed after 1 and 7 days. Conclusions: Formaldehyde gas significantly reduced the number of viable spores on both porous and nonporous materials in which the two surrogates exhibited similar log reductions to that of B. anthracis on most test materials. Significance and Impact of the Study: These results provide new comparative information for the decontamination of B. anthracis spores with surrogates on indoor surfaces using formaldehyde gas.

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Section: Introductionmentioning

confidence: 99%

Formaldehyde gas inactivation ofBacillus anthracis,Bacillus subtilis, andGeobacillus stearothermophilusspores on indoor surface materials

Rogers

Choi

Richter

et al. 2007

Journal of Applied Microbiology

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“…The gas is traditionally used as a fumigant to decontaminate laboratories of the biosafety level 3 or 4. Like chlorine dioxide fumigation vaporization of paraformaldehyde is a mature and commercialized technology for disinfection [3].…”

Section: Fumigation With Formaldehyde Gasmentioning

confidence: 99%

Principles and Practice of Disinfection of Biological Warfare Agents – How Clean is Clean Enough?

Richardt¹,

Hülseweh²

2013

CBRN Protection

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Biological Safety Cabinets, Decontamination or Sterilization with Paraformaldehyde

Cited by 2 publications

References 0 publications

Formaldehyde gas inactivation ofBacillus anthracis,Bacillus subtilis, andGeobacillus stearothermophilusspores on indoor surface materials

Formaldehyde gas inactivation ofBacillus anthracis,Bacillus subtilis, andGeobacillus stearothermophilusspores on indoor surface materials

Principles and Practice of Disinfection of Biological Warfare Agents – How Clean is Clean Enough?

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