Biological Rhythm Disruption Associated with Obesity in School Children

Pereira, Letícia Reis; Moreira, Fernanda Pedrotti; Reyes, Amanda Neumann; Bach, Suélen de Lima; Amaral, Paulinia Leal do; Motta, Janaína dos Santos; Silva, Ricardo Azevedo da; Jansen, Karen

doi:10.1089/chi.2018.0212

Cited by 9 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accompanied by economic development and lifestyle changes, the prevalence of childhood obesity has increased rapidly worldwide, leading to obesity-related metabolic diseases in adulthood, such as non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease [ 1 , 2 ]. Indeed, the unhealthy lifestyle and academic demands of children are increasingly interfering with biological rhythms, which might contribute to childhood obesity and negative health outcomes [ 3 , 4 ]. Therefore, it is essential to identify novel contributors to the underlying physiology of childhood obesity.…”

Section: Introductionmentioning

confidence: 99%

Evidence for disruption of diurnal salivary cortisol rhythm in childhood obesity: relationships with anthropometry, puberty and physical activity

Zhou

et al. 2020

BMC Pediatr

View full text Add to dashboard Cite

Background: The aim of this study was to examine the characteristics of diurnal cortisol rhythm in childhood obesity and its relationships with anthropometry, pubertal stage and physical activity. Methods: Thirty-five children with obesity (median age: 11.80[interquartile range 10.30, 13.30] and median BMI zscore: 3.21[interquartile range 2.69, 3.71]) and 22 children with normal weight (median age: 10.85[interquartile range 8.98, 12.13] and median BMI z-score: − 0.27[interquartile range − 0.88, 0.35]) were recruited. Saliva samples were collected at 08:00, 16:00 and 23:00 h. Cortisol concentrations at 3 time points, corresponding areas under the curve (AUCs) and diurnal cortisol slope (DCS) were compared between the two groups. Anthropometric measures and pubertal stage were evaluated, and behavioural information was obtained via questionnaires. Results: Children with obesity displayed significantly lower cortisol 08:00 (median [interquartile range]: 5.79[3.42,7.73] vs. 8.

show abstract

Section: Introductionmentioning

confidence: 99%

Evidence for disruption of diurnal salivary cortisol rhythm in childhood obesity: relationships with anthropometry, puberty and physical activity

Zhou

et al. 2020

BMC Pediatr

View full text Add to dashboard Cite

show abstract

“…In the present analyses we use a Morse wavelet with a low number of oscillations (defined by β=5 and γ=3, the frequencies of the two waves superimposed to create the wavelet(138)), similar to wavelets used in many circadian and ultradian applications(9,10,136–139). Additional values of β (3–8) and γ (2–5) did not alter the findings (data not shown). As WTs exhibit artifacts at the edges of the data being transformed, only the WT from p26 to p74 were analyzed further.…”

Section: Methodsmentioning

confidence: 78%

“…By characterizing rhythmic outputs that reflect underlying physiological change across adolescence, a greater understanding of typical progression can be garnered and the impact of exogenous hormone manipulation on temporal trajectories can be observed. Temporal disruption at all three timescales is associated with negative health outcomes in adults(66–71), and adolescence may be a sensitive period where disruptions have rapid(1) and potentially long-term health impacts(2,53,72,73). A growing proportion of teenage girls (estimated between 22-54% across the first two decades of the 21 st century(74, 75)) receive hormonal contraceptives for a variety of purposes, including pregnancy prevention(76) or treatment of menstrual symptoms(77), and acne(78).…”

Section: Introductionmentioning

confidence: 99%

Adolescent Development of Biological Rhythms: Estradiol Dependence and Effects of Combined Contraceptives

Grant¹,

Wilbrecht

Kriegsfeld

2021

Preprint

View full text Add to dashboard Cite

Purpose: Adolescence is a period of continuous development, including the maturation of endogenous rhythms across systems and timescales. Although these dynamic changes are well recognized, their continuous structure and hormonal dependence have not been systematically characterized. Given the well-established link between core body temperature (CBT) and reproductive hormones in adults, we hypothesized that high-resolution CBT can be applied to passively monitor pubertal development and disruption with high fidelity. Methods: To examine this possibility, we used signal processing to investigate the trajectory of CBT rhythms at the within-day (ultradian), daily (circadian), and ovulatory timescales, their dependence on estradiol, and the effects of hormonal contraceptives. Results: Puberty onset was marked by a rise in fecal estradiol (fE2), followed by an elevation in CBT and circadian power. This time period marked the commencement of 4-day rhythmicity in fE2, CBT, and ultradian power marking the onset of the estrous cycle. The rise in circadian amplitude was accelerated by E2 treatment, indicating a role for this hormone in rhythmic development. Contraceptive administration in later adolescence reduced CBT and circadian power and resulted in disruption to 4-day cycles that persisted after discontinuation. Conclusions: Our data reveal with precise temporal resolution how biological rhythms change across adolescence and demonstrate a role for E2 in the emergence and preservation of multiscale rhythmicity. These findings also demonstrate how hormones delivered exogenously in a non-rhythmic pattern can disrupt rhythmic development. These data lay the groundwork for a future in which temperature metrics provide an inexpensive, convenient method for monitoring pubertal maturation and support the development of hormone therapies that better mimic and support human chronobiology.

show abstract

“…Current research examining circadian rhythms and paediatric obesity is limited by the availability of longitudinal data. Furthermore, research is tainted with the presence of bias and reduced validity as a result of the predominant use of questionnaires, reduced sample sizes, lack of control groups, and a lack of cultural and socioeconomic diversity in recruitment cohorts [5,30,38,43,[87][88][89][90]. Future studies should aim to address these concerns through the inclusion of long-term exposure research, more accurate and specific objective measurements of sleep, control for confounding variables, and more widespread cohorts spanning diverse environments and socioeconomic and cultural backgrounds.…”

Section: Resultsmentioning

confidence: 99%

“…Sleep measures have also been recently recognized as potential risk factors for weight gain, leading to a recent surge in scientific attention. Specifically, the sleep-wake cycle is one of many important cyclical daily functions encompassed by circadian rhythms, which is the daily metabolic cycle of mammals primarily synchronized or entrained from exposure to the Earth's 24-hour light-dark cycle [5]. In this synthesis, we attempt to present some perspective on the impact of circadian rhythms on childhood and adolescent obesity, a correlation that is often proposed, but frequently overlooked in comparison to adult and generalized sleep research.…”

mentioning

confidence: 99%