Biological response to micron‐ and nanometer‐sized particles known as potential wear products from artificial hip joints: Part I: Selection and characterization of model particles

Gemeinert, Marion; Dörfel, I.; Griepentrog, Michael; Groß, Ulrich; Klaffke, D.; Knabe, C.; Kranz, I.; Österle, Werner

doi:10.1002/jbm.a.31952

Cited by 3 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was not possible to retain primary particles in suspension after dispersion in cell culture medium. Results of particle characterization were published in Part I 17. Though TM‐DAR corundum particles (NP) at least partly resisted agglomeration in cell culture medium, NAM particles were selected for biological testing because they seemed to be closer in size and shape to the real wear debris than TM‐DAR particles 17…”

Section: Resultsmentioning

confidence: 99%

“…In this study, two types of commercially available MP and NP of Al 2 O 3 were used. Among other particulate materials, these two powders were characterized comprehensively in part I 17. The MP (MR52 in Ref.…”

Section: Introductionmentioning

confidence: 99%

“…The MP (MR52 in Ref. 17) corresponded to a broad size distribution in the range 0.1–10 μm, whereas primary NP of type NAM17 corresponded to a size range 0.01–1 μm with two peaks at 30 and 200 nm, respectively. Both types of particles were observed in vivo 5 and in vitro 6 in the case of ceramic‐on‐ceramic THR.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biological response to micron‐ and nanometer‐sized particles known as potential wear products from artificial hip joints: Part II: Reaction of murine macrophages to corundum particles of different size distributions

Kranz

González

Dörfel

et al. 2008

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Macrophages play a pivotal role in tissue reaction and immune response. They recognize, phagocytose particles and generate cytokines to influence local cellular reactions. Friction and wear of implant components usually generates microparticles (MP) in a size range of 1-10 mum and nanoparticles (NP) in the range of 10-1000 nm. To investigate the possible impact of MP or NP on cellular reactions, we exposed murine macrophages (RAW264.7) to corundum MP and NP. The same mass was used in both NP and MP cell culture solutions, i.e. there were more NP than MP per identical volumes of culture solution. After 4, 24, 48, 72, and 96 h aliquots of cell culture supernatants were tested for different cytokines, growth factors and nitric oxide. Macrophages were stained with MGG (May-Grünwald Giemsa), counted and morphologically characterized by scanning electron microscopy and transmission electron microscopy. Particles were attached to cell surfaces and phagocytosed within cells. Cells stimulated with particles or lipopolysaccharides for positive controls showed surface modifications indicating enhanced function. Although only marginal differences between negative controls and particle-stimulated cells were observed in respect to cytokine production, exposure to corundum particles led to a decrease in the number of vital macrophages and to an increase in the number of giant cells. Corundum NP formed micron-sized aggregates in the cell culture medium and led to the production of more giant cells than MP. Sodiumdodecylsulfate polyacrylamide gel electrophoresis of the cell culture medium with particles proved the adsorption of proteins to particles.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biological response to micron‐ and nanometer‐sized particles known as potential wear products from artificial hip joints: Part II: Reaction of murine macrophages to corundum particles of different size distributions

Kranz

González

Dörfel

et al. 2008

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Attempts by the immune system to consume and remove these wear particles often leads to a state of a chronic inflammation. It has also been observed that wear debris cleared from the joint space by lymph or blood flow collects in the lymph nodes and other organs of the immune system 42, 44, 45…”

Section: Mechanical Failure Of Polymeric Biomaterialsmentioning

confidence: 99%

“…While these ceramics demonstrate excellent strength, stiffness, and lubricity, they have poor toughness and resistance to crack propagation. Attempts have been made to improve the surface properties of metals through the application of diamond‐like, titanium nitride, and chromium nitride coatings, but poor adhesion of these coatings to the metal substrate also results in debris that compromises the implant 45…”

Section: Mechanical Failure Of Polymeric Biomaterialsmentioning

confidence: 99%

Self‐healing biomaterials

Brochu

Craig

Reichert

2010

J Biomedical Materials Res

177

125

View full text Add to dashboard Cite

The goal of this review is to introduce the biomaterials community to the emerging field of self-healing materials, and also to suggest how one could utilize and modify self-healing approaches to develop new classes of biomaterials. A brief discussion of the in vivo mechanical loading and resultant failures experienced by biomedical implants is followed by presentation of the self-healing methods for combating mechanical failure. If conventional composite materials that retard failure may be considered zeroth generation self-healing materials, then taxonomically-speaking, first generation self-healing materials describe approaches that “halt” and “fill” damage, whereas second generation self-healing materials strive to “fully restore” the pre-failed material structure. In spite of limited commercial use to date, primarily because the technical details have not been suitably optimized, it is likely from a practical standpoint that first generation approaches will be the first to be employed commercially, whereas second generation approaches may take longer to implement. For self-healing biomaterials the optimization of technical considerations is further compounded by the additional constraints of toxicity and biocompatibility, necessitating inclusion of separate discussions of design criteria for self-healing biomaterials.

show abstract

Morphology and Dissolution Rate of Wear Debris from Silicon Nitride Coatings

Pettersson

Skjöldebrand

Filho

et al. 2016

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Silicon nitride (SiN x ) coatings have recently been introduced as a potential material for joint implant bearing surfaces, but there is no data on wear debris morphology nor their dissolution rate, something that could play a central role to implant longevity. In this study, wear debris was generated in a ball-ondisc setup in simulated body fluid. After serum digestion the debris was analysed with scanning electron microscopy and energy-dispersive x-ray spectroscopy. The particle dissolution rate was evaluated using

show abstract

Biological response to micron‐ and nanometer‐sized particles known as potential wear products from artificial hip joints: Part I: Selection and characterization of model particles

Cited by 3 publications

References 24 publications

Biological response to micron‐ and nanometer‐sized particles known as potential wear products from artificial hip joints: Part II: Reaction of murine macrophages to corundum particles of different size distributions

Biological response to micron‐ and nanometer‐sized particles known as potential wear products from artificial hip joints: Part II: Reaction of murine macrophages to corundum particles of different size distributions

Self‐healing biomaterials

Morphology and Dissolution Rate of Wear Debris from Silicon Nitride Coatings

Contact Info

Product

Resources

About