Abstract:The hypothesis is introduced, that nonrigid drug molecules interact with biological receptors in a well-defined but unknown conformation that need not belong to an energy minimum. A verification of this assumption has to include a match of conformation and chirality. Even the different action of pairs of nonrigid enantiomers allow one to recognize uniquely the important role of conformations because flexible molecules are partially able to avoid wrong attachment to the receptor. According to a simple model, a … Show more
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