Biological Relevance of RGD‐Integrin Subtype‐Specific Ligands in Cancer

Sani, Saidu; Messé, Melissa; Fuchs, Quentin; Pierrevelcin, Marina; Laquerrière, Patrice; Entz‐Werlé, Natacha; Reita, Damien; Étienne-Selloum, Nelly; Bruban, Véronique; Choulier, Laurence; Martin, Sophie; Dontenwill, Monique

doi:10.1002/cbic.202000626

Cited by 33 publications

(30 citation statements)

References 175 publications

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“…Another recognition system that is evident in multiple systems is that of the integrin family of molecules that recognize specific peptide sequences such as the RGD sequence in fibronectin or other sequences on ECM molecules such as collagen, laminin, and others (reviewed in [51][52][53][54]). Through a combination of different protein chains of family members, a variety of recognition specificities can be achieved.…”

Section: What Other Cell Surface Recognition Systems Could Msc Use Either As Pericytes In Tissues or As Circulating Cells?mentioning

confidence: 99%

What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options

Hart

2021

IJMS

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Mesenchymal stem cells, also called medicinal signaling cells (MSC), have been studied regarding their potential to facilitate tissue repair for >30 years. Such cells, derived from multiple tissues and species, are capable of differentiation to a number of lineages (chondrocytes, adipocytes, bone cells). However, MSC are believed to be quite heterogeneous with regard to several characteristics, and the large number of studies performed thus far have met with limited or restricted success. Thus, there is more to understand about these cells, including the molecular recognition systems that are used by these cells to perform their functions, to enhance the realization of their potential to effect tissue repair. This perspective article reviews what is known regarding the recognition systems available to MSC, the possible systems that could be looked for, and alternatives to enhance their localization to specific injury sites and increase their subsequent facilitation of tissue repair. MSC are reported to express recognition molecules of the integrin family. However, there are a number of other recognition molecules that also could be involved such as lectins, inducible lectins, or even a MSC-specific family of molecules unique to these cells. Finally, it may be possible to engineer expression of recognition molecules on the surface of MSC to enhance their function in vivo artificially. Thus, improved understanding of recognition molecules on MSC could further their success in fostering tissue repair.

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Section: What Other Cell Surface Recognition Systems Could Msc Use Either As Pericytes In Tissues or As Circulating Cells?mentioning

confidence: 99%

What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options

Hart

2021

IJMS

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“…Peptides can also disturb the interaction between tumour cells and tumour-associated macrophages (3) or other immune cells ( 4) and as such promote anti-cancer immune responses or attenuate tumourigenic signalling (Thundimadathil, 2012). The author concluded that the use of peptides (not including monoclonal antibodies) will become more common in future cancer therapy because of their chemical versatility and their target specificity to receptors in a tumour, such as the RGD moiety in receptors found in tumour neovasculature (Sani et al, 2021).…”

Section: Immune Cellsmentioning

confidence: 99%

Bioactive peptides from microalgae: Focus on anti‐cancer and immunomodulating activity

Skjånes

Aesöy

Herfindal

et al. 2021

Physiologia Plantarum

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In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new therapeutics is needed is cancer therapy. As cancer therapy often cause severe side effects and loose effect due to development of drug resistance, new therapeutic agents are needed. Treating cancer by modulating the immune response using peptides has led to unprecedented responses in patients. In this review, we want to elucidate the potential for microalgae as a source of new peptides for possible use in cancer management. Among the limited studies on anti-cancer effects of peptides, positive results were found in a total of six different forms of cancer. The majority of studies have been performed with different strains of Chlorella, but effects have also been found using peptides from other species. This is also the case for peptides with immunomodulating effects and peptides with other health-promoting effects (e.g., role in cardiovascular diseases). However, the active peptide sequence has been determined in only half of the studies. In many cases, the microalga strain and the cultivation conditions used for producing the algae have not been reported. The low number of species that have been explored, as opposed to the large number of species available, is a clear indication that the potential for new discoveries is large. Additionally, the availability and cost-effectiveness of microalgae make them attractive in the search for bioactive peptides to prevent cancer.

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“…Integrins are heterodimeric transmembrane protein families, and among these integrins, ανβ3 and ανβ5 are overexpressed in endothelial cells of many types of cancers and are emerging as markers of tumoral neo-angiogenesis. Indeed, many investigations are reported in the field of ανβ3 integrin-mediated bioactive RGD motif ( Figure 2 a)-containing peptides [ 30 ].…”

Section: Passive and Active Targetingmentioning

confidence: 99%

Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides

et al. 2021

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Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can facilitate cellular intake. This review focuses on micelles achieved by self-assembling or mixing peptide-grafted surfactants or peptide-decorated amphiphilic copolymers. Nanovectors loaded with hydrophobic or hydrophilic cytotoxic drugs or with gene silence sequences and externally functionalized with natural or synthetic peptides are described based on their formulation and in vitro and in vivo behaviors.

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Biological Relevance of RGD‐Integrin Subtype‐Specific Ligands in Cancer

Cited by 33 publications

References 175 publications

What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options

What Molecular Recognition Systems Do Mesenchymal Stem Cells/Medicinal Signaling Cells (MSC) Use to Facilitate Cell-Cell and Cell Matrix Interactions? A Review of Evidence and Options

Bioactive peptides from microalgae: Focus on anti‐cancer and immunomodulating activity

Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides

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