Biological rationale and clinical experience with hyperthermia

Engin, K.

doi:10.1016/0197-2456(95)00078-x

Cited by 73 publications

(43 citation statements)

References 117 publications

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“…Oral squamous carcinoma is one of the most common cancers (Fiaschi et al 2005), and human tongue squamous carcinoma cells HSC-4 are multiplied in planar state. Hyperthermia can be especially effective in the treatment of superficially seated malignant tumors (Engin 1996), and enhance the susceptibility of cells to diverse anticancer drugs, especially of alkylating agents (Kampinga 2006). Asc6Palm, which is a lipophilic and autooxidation-resistant derivative of Asc, is expected to exert inhibition of proliferation of HSC-cells through intracellular ascorbate enrichment and the resultant hydrogen-peroxide-generating action in combination with hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

Anticancer effects of 6-o-palmitoyl-ascorbate combined with a capacitive-resistive electric transfer hyperthermic apparatus as compared with ascorbate in relation to ascorbyl radical generation

et al. 2011

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The aim of the present study is to determine the anti-proliferative activity of 6-o-palmitoyl-L-ascorbic acid (Asc6Palm) that is a lipophilic derivative of L-ascorbic acid (Asc), on human tongue squamous carcinoma HSC-4 cells by combined use of hyperthermia in comparison to Asc. Asc6Palm or Asc were administered to HSC-4 cells for 1 h, to which hyperthermia at 42°C was applied for initial 15 min. After further 1-72 h incubation at 37°C, cell proliferation was determined with Crystal Violet staining. Ascorbyl radical (AscR) in HSC-4 cell suspension was measured by electron spin resonance (ESR), and cell morphology was observed with scanning electron microscopy (SEM). At 37°C, 4 mM Asc or 0.35 mM Asc6Palm were enough to suppress proliferation of HSC-4 cells. By combined use of hyperthermia at 42°C, cell proliferation was decreased when compared to 37°C. After Asc of 4 mM was incubated with HSC-4 cell suspensions at 37°C or 42°C for 0-180 min, the signal intensity of ascorbyl radical (AscR) by ESR was not different regardless of the presence or absence of cells at 37°C, whereas AscR signal was enlarged in the presence of HSC-4 cells at 42°C. It was suggested that oxidation of Asc occurred rapidly in HSC-4 cells by hyperthermia, and thereby enhanced the anti-proliferative activity. By SEM observation, the surface of HSC-4 cells treated with Asc6Palm revealed distinct morphological changes. Thus, the combined regimen of Asc6Palm and hyperthermia is expected to exert a marked antitumor activity.

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Section: Introductionmentioning

confidence: 99%

Anticancer effects of 6-o-palmitoyl-ascorbate combined with a capacitive-resistive electric transfer hyperthermic apparatus as compared with ascorbate in relation to ascorbyl radical generation

et al. 2011

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“…Hyperthermia involves applying an alternating magnetic field of suitable frequency that produces heat dissipation through the oscillation of the internal magnetic moment of superparamagnetic particles. Hyperthermia using magnetic nanoparticles either alone, or in association with classical chemo-or radiotherapies, has been recognized as a useful therapeutic modality in the treatment of malignant tumors [10,11] because the neoplastic cells are more thermosensitive than normal cells [12]. For hyperthermic applications, nanomagnetic particles should have high magnetization values in order to generate high thermal energies and size smaller than 50 nm with a narrow particle size distribution.…”

Section: Introductionmentioning

confidence: 99%

Pullulan acetate coated magnetite nanoparticles for hyper-thermia: Preparation, characterization and in vitro experiments

et al. 2010

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Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity and cellular uptake of the magnetic nanoparticles were examined. The hyperthermic effect of the magnetic nanoparticles on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that the PA coated magnetic nanoparticles (PAMNs) had spherical morphology. Dynamic light scattering (DLS) showed that the size distribution of PAMNs was unimodal,with an average diameter of 25.8 nm ± 6.1 nm. The presence of the adsorbed layer of PA on the magnetite surface was confirmed by Fourier transform infrared (FTIR) spectroscopy. Magnetic measurements revealed that the saturation magnetization of the PAMNs reached 51.9 emu/g and the nanoparticles were superparamagnetic. Thermogravimetric analysis (TGA) showed that the Fe 3 O 4 particles constituted 75 wt% of the PAMNs. The PAMNs had good heating properties in an alternating magnetic field. Cytotoxicity assay showed that PAMNs exhibited no significant cytotoxicity against L929 cells. TEM results showed that a large number of PAMNs were internalized into KB cells. PAMNs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia. These novel magnetic nanoparticles have great potential as magnetic hyperthermia mediators.

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“…22,23 Furthermore, hyperthermia can sensitize cancer cells to the cytotoxic effects of radiotherapy and chemotherapy by enhancing membrane permeability, increasing intracellular accumulation of chemotherapeutic agents, inhibiting DNA repair, activating antiangiogenic protein production, or promoting immunologic host defenses in tumor tissue. 24,25 Although the effects of hyperthermia on cancer cells have been well documented, the influence of hyperthermia on the tumor stromal tissue or cells that interact with the cancer cells has not been studied. The goal of this study was to evaluate the effects of culture medium conditioned by heat-shocked MSCs, from adipose tissue and amniotic fluid, on the viability and growth of the human ovarian adenocarcinoma cell line SK-OV-3.…”

mentioning

confidence: 99%

Hyperthermia‐treated mesenchymal stem cells exert antitumor effects on human carcinoma cell line

Cho

Park

Kim

et al. 2009

Cancer

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Biological rationale and clinical experience with hyperthermia

Cited by 73 publications

References 117 publications

Anticancer effects of 6-o-palmitoyl-ascorbate combined with a capacitive-resistive electric transfer hyperthermic apparatus as compared with ascorbate in relation to ascorbyl radical generation

Anticancer effects of 6-o-palmitoyl-ascorbate combined with a capacitive-resistive electric transfer hyperthermic apparatus as compared with ascorbate in relation to ascorbyl radical generation

Pullulan acetate coated magnetite nanoparticles for hyper-thermia: Preparation, characterization and in vitro experiments

Hyperthermia‐treated mesenchymal stem cells exert antitumor effects on human carcinoma cell line

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