Biological Properties of Oleanolic Acid Derivatives Bearing Functionalized Side Chains at C-3
Gianfranco Fontana,
Natale Badalamenti,
Maurizio Bruno
et al.
Abstract:Triterpene acids are a class of pentacyclic natural carboxylic compounds endowed with a variety of biological activities including antitumor, antimicrobial, and hepatoprotective effects. In this work, several oleanolic acid derivatives were synthesized by structurally modifying them on the C-3 position. All synthesized derivatives were evaluated for possible antibacterial and antiviral activity, and among all the epimers, 6 and 7 demonstrated the best biological activities. Zone-of-inhibition analyses were con… Show more
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