Biological properties of novel mono and double-decker hexadeca-substituted metal phthalocyanines

Abstract

This study presents the synthesis of a new phthalonitrile derivative namely 4,5-bis(3,5-bis(trifluoromethyl)phenoxy)-3,6-bis(hexyloxy)phthalonitrile (1) and its mono metal {Zn (2), Lu (CH3COO) (3)}/double-decker lutetium (4) phthalocyanines. All the newly synthesized compounds...

Biological Applications of The Newly Designed Phthalocyanine‐Modified Gold Nanorods

“…On the other hand, the center of the phthalocyanine ring can be placed by different metal cations. [19][20][21][22][23][24][25][26][27][28][29][30] Metal ions with higher coordination number (more than 2) bear axial ligand(s) decreasing π-π interactions between the phthalocyanine rings, as well. The selection of suitable substituents and metal ions can refine the characteristic properties of phthalocyanines and make them an appropriate agent for a specific purpose.…”

“…For instance, the biological activities of lanthanidecontaining phthalocyanines have attracted attention owing to the similarity of lanthanides to calcium. [21,22] Due to small size, high electronegativity, low polarizability, three nonbonding electron pairs, and high overlap between 2s and 2p, the fluorinated compounds exhibit excellent physical characteristics affecting the biological activities by changing absorption, compound binding, and transport properties. Organofluorine molecules can be soluble in non-polar and polar solvents.…”

“…The periphery of the phthalocyanine ring alters by substitution of diverse long and bulky substituents on peripheral and/or non‐peripheral positions. On the other hand, the center of the phthalocyanine ring can be placed by different metal cations [19–30] . Metal ions with higher coordination number (more than 2) bear axial ligand(s) decreasing π–π interactions between the phthalocyanine rings, as well.…”

“…These modifications are essential for the use of phthalocyanines in a vast range of scientific applications consisting of chemistry, physics, nanotechnology, biology, and medicine. For instance, the biological activities of lanthanide‐containing phthalocyanines have attracted attention owing to the similarity of lanthanides to calcium [21,22] …”

Novel non-peripheral mercaptopyridine-substituted mono- and double-decker lutetium(iii) phthalocyanines: synthesis, photophysicochemical and electrochemical properties

“…Phthalocyanines (Pcs), which are called porphyrin analogs and contain four indole units, have exceptional optical, chemical, and physical capabilities because of the strong electron transfers caused by their aromatic 18 π-electrons in the Pc ring. 1 Pcs, mainly metallophthalocyanines (MPcs), are widely utilized in the dye and pigment industries, but they are also investigated for usage in other fields 2 including organic solar cells, 3 photodynamic therapy (PDT), 4 gas sensors, 5 catalysis, 6 biosensors, 7 and nonlinear optics. 8 PDT is a potential cancer treatment that uses a photosensitizing chemical and light to create reactive oxygen species in cells.…”