Biological properties and therapeutic applications of cannabidiol

Abstract

Cannabis sp. has important pharmacological activities, so it has been the focus of attention of the scientific community. Through the search for new drugs, it was found that cannabinoids present in the plant can modulate transient potential receptors (TPR). Cannabidiol (CBD), also known as "medical marijuana", represents the second most abundant phytocannabinoid of the Cannabis plant and it is widely used in the management of pain, nausea and migraine in cancer patients. In fact, CBD exhibits various therapeutic effects and constitutes up to 40% of Cannabis extracts and it is devoid of the typical psychological effects of Cannabis used in social use as a psychoactive drug, and has low affinity for endocannabinoid receptors CB1 and CB2. Thus, this article aims to conduct an integrative review of CBD and its potential benefits for human health. The results of this research confirmed CBD therapeutic actions in diseases such as schizophrenia, anxiety, epilepsy and motor disorders such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, neuropathic pain, childhood convulsive disorders, Lennox-Gastaut and Dravet syndromes. Thus, cannabidiol has an important relevance for medical applications and also has anti-inflammatory, antioxidant, anticonvulsant, anxiolytic, neuroprotective, antipsychotic, antiemetic, analgesic and antibiotic activities.

New Polymeric Hydrogels with Cannabidiol and α-Terpineol as Potential Materials for Skin Regeneration—Synthesis and Physicochemical and Biological Characterization

“…A promising compound in treating various skin diseases is cannabidiol (CBD), which has a comprehensive therapeutic effect [ 15 ]. Because the endocannabinoid system is a fundamental molecular system responsible for controlling and maintaining homeostasis in the body, it is nowadays a common target of pharmacotherapy [ 16 ].…”