Biological Properties and Clinical Use of Calf Thymus Extract TFX-Polfa

Thymic hormones ? A clinical update

“…TFX was found to induce clinical improvements accompanied by a decrease in rheumatoid factor levels and normalization of the hypergammaglobulinemia in 16 out of 20 RA patients [88]. These studies have also shown an improvement in clinical and laboratory findings in 60-80% of CAH patients, while no promising results were observed in MS patients [88]: Thymulin is another TH which has shown promising preliminary results in the treatment of RA patients, since a clear improvement of the clinical signs, particularly those related to inflammation, has been observed [7]. Additionally, TP5 has also been demonstrated to significantly improve the clinical status of some, but not all, RA patients [100].…”

“…Several of the TH preparations, including TF5, TS, TP5, thymulin, THF, and TFX, have already entered clinical trials [2,7,18,81,83,88,103]. The administration of these preparations to children with primary immunodeficiencies is based on the effects observed in animals and on patient's PBL in vitro and is an attempt to replace the activity of the endocrine thymus.…”

“…Reviews have recently been published describing in detail the therapeutic effects of TH in cancer patients [39,81,83,88]. Reviews have recently been published describing in detail the therapeutic effects of TH in cancer patients [39,81,83,88].…”

“…Some of these preparations are partially purified, i. e., thymosin fraction 5 (TF5) [36,54], thymostimulin (TS) (TP1) [28], thymic humoral factor (THF) [97], and thymic factor X (TFX) [87,88], while others are homogeneous preparations, like thymosin ~. Some of these preparations are partially purified, i. e., thymosin fraction 5 (TF5) [36,54], thymostimulin (TS) (TP1) [28], thymic humoral factor (THF) [97], and thymic factor X (TFX) [87,88], while others are homogeneous preparations, like thymosin ~.…”

Thymus-Derived Peptides in the Treatment of Viral Chronic Hepatitis

“…In 1980 Dabrowski et al [23], using a calf thymic extract called thymomodulin, treated patients with CH-B and noted im provements in T-cell-mediated immune reac tivity but did not report on the clinical changes. In a subsequent report on a group of 21 patients, clinical improvements were de scribed that were characterized by normaliza tion of serum aminotransferase levels in 13 (60%) patients [24][25][26]. Resolution of hepatic necroinflammatory changes either completely or partially occurred in 14 (67%) of the pa tients.…”