Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives

Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives

“…It is known that many 1,3,4-thiadiazoles have biological activities like antibacterial [9], antimycobacterial [10], antimycotic [11], antifungal [12], antidepression [13], analgesic [14] and anti-inflammatory [15]. Nitrogen containing heterocyclic ring such as pyrimidine and its derivatives have been reported as anti-microbial [16], analgesic, anti-viral, anti-inflammatory [17], anti-HIV [18], anti-tubercular [19], anti-tumour [20], anti-neoplastic [21], anti-malarial [22], diuretic [23], cardiovascular [24] agents. Here in, we report a series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives.…”

Synthesis of Novel Steroidal N-Substituted Pyrimidine-2, 4-Diones: A New Entry to Steroidal Azaheterocycles.

“…[1] Many steroidal heterocyclic compounds have been reported to possess various therapeutic activities. [2,3] Condensed pyrimidine derivatives have been reported as anti-tumour [4] , anti-neoplastic [5] ,…”

Novel quinazoline and pyrido[2,3-d]pyrimidine derivatives and their hydroselenite salts as antitumoral agents

“…Natural organic and inorganic sources of Se as well as synthetic organoselenium compounds have been shown to be effective and safe in the treatment and prevention of cancer. [23][24][25][26] The observations outlined above, along with our experience in the synthesis and antitumoral studies related to quinazoline and pyrido [2,3-d]pyrimidines, [27][28][29][30][31] so as a continuation with our efforts in the search of new selenium derivatives with antitumoral properties [32][33][34][35][36][37][38] enthused us to develop new 2,4-disubstituted quinazoline and pyrido [2,3-d]pyrimidine derivatives. The linkages investigated were (-NH-), which was inserted in positions 2 and/or 4, and sulfur which was introduced in the 2-position.…”