2012
DOI: 10.6064/2012/607427
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Biological Processes that Prepare Mammalian Spermatozoa to Interact with an Egg and Fertilize It

Abstract: In the mouse and other mammals studied, including man, ejaculated spermatozoa cannot immediately fertilize an egg. They require a certain period of residence in the female genital tract to become functionally competent cells. As spermatozoa traverse through the female genital tract, they undergo multiple biochemical and physiological changes collectively referred to as capacitation. Only capacitated spermatozoa interact with the extracellular egg coat, the zona pellucida. The tight irreversible binding… Show more

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Cited by 12 publications
(7 citation statements)
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“…Siglecs 1, 2, 6 and 10 were expressed on the plasma membrane in the acrosomal cap region. The acrosomal cap is central to several sperm functions including capacitation, binding to the zona pellucida, acrosomal exocytosis, and it is also a calcium store within the sperm (Wassarman 1987, Tulsiani et al 1998, Herrick et al 2005, Berruti & Paiardi 2011, Tulsiani & Abou-Haila 2012, Buffone et al 2014. Sialylated ligands in several species are central to sperm binding to the oviductal epithelium during the formation of the sperm-oviductal reservoir as well as their subsequent release and capacitation (Hung & Suarez 2010, Talevi & Gualtiere 2010, Miller 2015, and sperm surface Siglecs may play a role in these processes.…”
Section: Discussionmentioning
confidence: 99%
“…Siglecs 1, 2, 6 and 10 were expressed on the plasma membrane in the acrosomal cap region. The acrosomal cap is central to several sperm functions including capacitation, binding to the zona pellucida, acrosomal exocytosis, and it is also a calcium store within the sperm (Wassarman 1987, Tulsiani et al 1998, Herrick et al 2005, Berruti & Paiardi 2011, Tulsiani & Abou-Haila 2012, Buffone et al 2014. Sialylated ligands in several species are central to sperm binding to the oviductal epithelium during the formation of the sperm-oviductal reservoir as well as their subsequent release and capacitation (Hung & Suarez 2010, Talevi & Gualtiere 2010, Miller 2015, and sperm surface Siglecs may play a role in these processes.…”
Section: Discussionmentioning
confidence: 99%
“…Spermatozoa are produced in the seminiferous tubules of the testes via a complex, highly regulated differentiation process called spermatogenesis. Testicular spermatozoa are nonfunctional and lack the ability to naturally fertilise an oocyte (Jones, 1999;Tulsiani & Abou-Haila, 2012;Xu, Washington, & Hinton, 2014;Zhou, De Iuliis, Dun, & Nixon, 2018). After being released from the germinal epithelium in the process called spermiation, spermatozoa pass through tiny channels, the rete testis and the efferent ducts into the epididymis, where they undergo a complicated maturation process leading to biochemical, physiological and functional changes.…”
Section: Introductionmentioning
confidence: 99%
“…Sialyl CD15 (CD15s) (α-Neup5Ac-(2, 3)-β-Galp- (1,4)[α-Fucp-(1,3)]-GlcpNAc-R) is a tetrasaccharide epitope that was first detected in a ganglioside fraction from human kidney [6] and in human milk [7]. CD15s has been shown to play a key role in cell-cell recognition in sperm-egg fertilisation [8] and in extravasation of leukocytes [9]. Both CD15 and CD15s are expressed in a variety of non-neoplastic cells such as granulocytes, monocytes [10], epithelial cells [11] and neurons [12,13].…”
Section: Introductionmentioning
confidence: 99%