Biological Potential of the Main Component, Thymoquinone, of Nigella sativa in Pulp Therapy-In Vitro Study

Alamoudi, Rana A; Alamoudi, Soha A; Alamoudi, Ruaa A

doi:10.37247/pabios2ed.2.22.9

Prime Archives in Biosciences 2022

DOI: 10.37247/pabios2ed.2.22.9

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Biological Potential of the Main Component, Thymoquinone, of Nigella sativa in Pulp Therapy-In Vitro Study

Rana A Alamoudi,

Soha A Alamoudi,

Ruaa A Alamoudi

Abstract: This work is designed to assess the antimicrobial efficacy, chelating efficacy, and dissolving capability of the bioactive agent of the Nigella sativa plant (thymoquinone). Four freezedried microorganisms were studied. Each species was treated with either 6% sodium Hypochlorite, thymoquinone, or sterile

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Thymoquinone: Hydroxypropyl-β-cyclodextrin Loaded Bacterial Cellulose for the Management of Wounds

et al. 2022

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The need for more advantageous and pharmaceutically active wound dressings is a pressing matter in the area of wound management. In this study, we explore the possibility of incorporating thymoquinone within bacterial cellulose, utilising cyclodextrins as a novel method of solubilising hydrophobic compounds. The thymoquinone was not soluble in water, so was incorporated within hydroxypropyl-β-cyclodextrin before use. Thymoquinone: hydroxypropyl-β-cyclodextrin inclusion complex produced was found to be soluble in water up to 7% (w/v) and was stable with no crystal formation for at least 7 days with the ability to be loaded within the bacterial cellulose matrix. The inclusion complex was found to be thermally stable up to 280 °C which is far greater than the production temperature of 80 °C and was stable in phosphate-buffered saline and extraction solvents in permeation and dose experiments. The adhesion properties of the Thymoquinone: hydroxypropyl-β-cyclodextrin loaded bacterial cellulose dressings were tested and found to be 2.09 N. Permeation studies on skin mimicking membrane Strat-M showed a total permeated amount (0–24 h) of 538.8 µg cm−2 and average flux after a 2 h lag of 22.4 µg h−1 cm−2. To the best of our knowledge, the methods outlined in this study are the first instance of loading bacterial cellulose with thymoquinone inclusion complex with the aim of producing a pharmaceutically active wound dressing.

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Thymoquinone: Hydroxypropyl-β-cyclodextrin Loaded Bacterial Cellulose for the Management of Wounds

et al. 2022

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Biological Potential of the Main Component, Thymoquinone, of Nigella sativa in Pulp Therapy-In Vitro Study

Cited by 1 publication

References 22 publications

Thymoquinone: Hydroxypropyl-β-cyclodextrin Loaded Bacterial Cellulose for the Management of Wounds

Thymoquinone: Hydroxypropyl-β-cyclodextrin Loaded Bacterial Cellulose for the Management of Wounds

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