Biological potential of Stillingia oppositifolia

Abstract

Organic extracts from leaves and stems of Stillingia oppositifolia Baill. ex Müll. Arg., Euphorbiaceae, were screened for antifungal and cytotoxic properties. The extracts presented Minimum Inhibitory Concentration values around 250 μg.mL -1 against Candida krusei and Candida tropicalis, and around 63 μg.mL -1 for Paracoccidioides brasiliensis. They were tested on three human cell lines (UACC-62, MCF-7, and TK-10), disclosing GI50 values, (concentration able to inhibit 50% of the cell growth) ranging from 50 to 100 μg.mL -1 . Organic extract from stems furnished hexanic, dichloromethanic and aqueous phases after partition. Chromatographic fractionation of the hexanic soluble phase of the stems yielded aleuritolic acid 3-acetate, β-sitosterol, 3-epi-β-amyrin, β-amyrone and palmitic acid. These compounds showed antifungal and cytotoxic activities in the same range as the organic crude extract and low toxic effect against mononuclear cells obtained from human peripheral blood. This is the first report on chemical and biological potential of S. oppositifolia.

Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying properties

“…Alpha-BA (16) and Aα-BA (17) show similar inhibitory activity against TPA-induced inflammation in mice [ 50 ] and selectively inhibit COX-1 [ 66 ]. β-amyrenone (18) and 3-epi-β-amyrin (19) show antifungal and cytotoxic activities in the same range as the organic crude extract and have low-level toxic effects on mononuclear cells obtained from human peripheral blood [ 79 ]. Furthermore, olibanumol E (22) inhibits NO production in LPS-activated mouse peritoneal macrophages [ 80 ] and also shows inhibitory activity against TPA-induced inflammation in mice [ 50 ].…”

Tri- and Diterpenoids from Stillingia loranthacea as Inhibitors of Zika Virus Replication

“…Pax] . The extracts of leaves and latex of some species of this genus have shown antifungal, antiviral, and cytotoxic activities. − …”

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata

“…19 The genus Stillingia (Euphorbiaceae) is represented by 30 species distributed throughout Latin and North America and various islands of the Pacific and Indian Oceans. The leaf and latex extracts of some species have been reported to possess cytotoxic, 20 proteolytic, 21 and antifungal 22 properties. The roots of Stillingia sylvatica are used for preparing a therapeutic composition to treat various ailments such as syphilis, bronchitis, constipation, hemorroids, diseases of the skin, and cancer.…”

“…The roots of Stillingia sylvatica are used for preparing a therapeutic composition to treat various ailments such as syphilis, bronchitis, constipation, hemorroids, diseases of the skin, and cancer . Only three Stillingia species have been investigated chemically so far. ,, From the roots of S. sylvatica , Adolf and Hecker reported the isolation of diterpene esters of the daphnane and tigliane types . More recently, Dräger and colleagues reported the isolation of two novel diterpenes, tonantzitlolones A and B, sharing the rare flexibilane backbone, from S. sanguinolenta.…”

“…23 Only three Stillingia species have been investigated chemically so far. 22,24,25 From the roots of S. sylvatica, Adolf and Hecker reported the isolation of diterpene esters of the daphnane and tigliane types. 24 More recently, Drager and colleagues reported the isolation of two novel diterpenes, tonantzitlolones A and B, sharing the rare flexibilane backbone, from S. sanguinolenta.…”