Biological potential of pyrimidine derivatives in a new era

Conversion of Curcumin into Heterocyclic Compounds as Potent Anti-diabetic and Anti-histamine Agents

“…The inhibition of this compound may be due to pyrimidin and pyran rings. [12][13][14][15][16][17][18][19] Our results agree with Najafian 11) he reported that curcumin inhibited α-amylase with an half maximal inhibitory concentration IC 50 value 51.32 µM. Curcumin at different concentrations, i.e., 10, 50, 100 µg showed dose dependent effect where as the standard indomethacin at 50 and 100 µg exhibited much higher activity.…”

“…Compounds 5, 6 and 7 exhibited significant inhibitory activity against histamine and was comparable with that of original curcumin. Compound 5 showed 29.35±2.5, 36.82±2.1, [12][13][14][15][16][17][18][19] Curcumin has been reported to have anti-allergic effects and can inhibit the release of histamine from mast cells. 27) The histamine release from compound 48/80-treated RPMCs was reduced in a dose-dependent manner by curcumin (58 and 80% inhibition at 25 and 50 µM, respectively).…”

“…10) Since curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) could be viewed as a flavonoid of polyphenolic compounds, in this investigation we researched the inhibitory effect of curcumin on α-amylase and the effect of curcumin orally on blood glucose levels in streptozotocin (STZ) induced diabetic and normal rats. 11) Pyrimidines exhibit a wide broad as biologically active agents they showed antioxidant, 12) antifungal, 13) antibacterial, 14) antihypertensive, 15) antitumor, 16) activity. Also pyranone which is six membered oxygenated unsaturated ester heterocyclic compounds that shares chemical and physical properties reminiscent of alkene and aromatic compounds showed a wide range of biological activity as antileukemic, 17) antitumor, 18) anti-fungal 19) inhibiting, human immunodeficiency virus (HIV) protease 20) qualities also it was found that In the last several decades, cyclohexenone derivatives have received considerable attention due to their wide range of applications.…”

Therapeutic potential of heterocyclic pyrimidine scaffolds

“…Antioxidant compounds are the agents that neutralize free radicals, which scavenge reactive oxygen species, may have potent value in preventing the onset and propagation of oxidative diseases such as neurovascular, cardiovascular diseases. Pyrimidine and its derivatives have recently attracted the attention of medicinal chemists in exploring their potential as antioxidant agents [ 1 ].…”

“…Pyrimidine which is an integral part of DNA and RNA imparts diverse pharmacological properties. The pyrimidine have been isolated from the nucleic acid hydrolyses and much weaker base than pyridine and soluble in water [ 1 ]. Pyrimidine and its derivatives have been described with a wide range of biological potential i.e.…”