Biological potential of Moluccella laevis L. aerial parts, family Lamiaceae (Labiatae)

Abstract

The current study aimed to determine the various in vivo biological activities of Moluccella laevis L. aerial parts. The antiinflammatory activity demonstrated after 2 h, for both the total ethanolic extract (TEE) and the petroleum ether (Pet. ether) fraction, exhibited the same percentage of inhibition (26.24%) as that of the indomethacin, whereas the following hour showed results quite higher than that of the positive control. Additionally, the TEE showed higher antipyretic activity compared to the used standard acetylsalicylic acid with a rapid onset (30 min) and a longer duration exhibiting the maximum activity. After 4 h from the beginning of the experiment, the Pet. ether, ethyl acetate (EtOAc) and aqueous fractions displayed nearly the same effect as that of acetylsalicylic acid, which lasted up to 5 h. Moreover, the aqueous fraction exhibited the maximum analgesic activity with a rapid onset and a longer duration followed by the Pet. ether fraction, TEE and the EtOAc fraction. These activities could be explained by the presence of the highest amount of phenolic and flavonoidal contents, which are found in both EtOAc fraction and TEE. Due to the pronounced results of M. laevis L. aerial parts, it can be considered as a success of natural products in further drug discovery.

Phytochemical and biological studies of Panicum antidotale aerial parts ethanol extract supported by molecular docking study

“…Groups 3–5 were orally administered 125, 250, and 500 mg/kg of PAAPEE, respectively. Following treatment, the body temperature of all animals in all groups was measured at 0, 1, 2, 3, and 4 h ( Rakib et al, 2020 ; Abdelaty et al, 2021 ).…”

“…Gradients A (H 2 O: AA-94:6, pH = 2.27), B (CAN 100%), 0-15 min = 15% V, 15-30 min = 45% B, and 30-45 min = 45% B were used in the mobile phase. A 280-nm UV-visible detector (SPD-10AV) and an LC-10AV pump were used (Hamed et al, 2021).…”