Biological, non-antibiotic properties of semi-synthetic and chemically modified tetracyclines — a structured, annotated bibliography

Greenwald, Robert A.; Lm, Golub

doi:10.1007/978-3-0348-8306-1_8

Cited by 1 publication

(1 citation statement)

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“…With the generation of a large number of 7-, 9-, and 6−13 monosubstituted and 7- and 9-symmetrical and unsymmetrical disubstituted tetracyclines, their structure−activity relationships to antibacterial activity will be the subject of forthcoming publications. More recently, the biological activities of some tetracyclines have been described in eukaryotic systems, modulating inflammation, neurodegenerative, and cellular signaling pathways related to nitric oxide and cytokine production, further warranting the production of new tetracycline structural classes …”

Section: Discussionmentioning

confidence: 99%

Versatile and Facile Synthesis of Diverse Semisynthetic Tetracycline Derivatives via Pd-Catalyzed Reactions

et al. 2003

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A diverse collection of tetracycline derivatives has been synthesized utilizing Heck, Suzuki, and other palladium-coupling reactions via tetracycline arenediazonium and iodoarene salts. Large numbers of tetracyclines are now possible via these reactions, including numerous upper periphery derivatives of doxycycline, minocycline, sancycline, and methacycline modified at positions C7, C9, and C6-C13 on the tetracycline naphthacene ring. Application of palladium-coupling reactions to the tetracyclines has yielded new tetracycline classes with differing structural attributes, greatly increasing the structural diversity of this family of antibiotics, one of the last of the early antibiotic families to be expanded by organic and medicinal chemistry.

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Section: Discussionmentioning

confidence: 99%