2022
DOI: 10.1186/s12884-022-04716-w
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Biological networks in gestational diabetes mellitus: insights into the mechanism of crosstalk between long non-coding RNA and N6-methyladenine modification

Abstract: Background Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy. The mechanism underlying the crosstalk between long non-coding RNAs (lncRNAs) and N6-methyladenine (m6A) modification in GDM remain unclear. Methods We generated a lncRNA-mediated competitive endogenous RNA (ceRNA) network using comprehensive data from the Gene Expression Omnibus database, published data, and our preliminary findings. m6A-related ln… Show more

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Cited by 9 publications
(8 citation statements)
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“… 32 Furthermore, YTHDF3 levels were also found to be upregulated in the placentas of gestational diabetes mellitus (GDM), showing excellent classifying power for the GDM and control groups. 33 These findings indicate a critical role for the m6A readers YTHDF2 and YTHDF3 in the occurrence, progression, and prevention of DM, and could thus help to restore the damaged functions of DM-BMSCs to improve the success rate of implantation. However, the role of YTHDF2 and YTHDF3 in DM-BMSCs and their effects on the implant success rate require further exploration.…”
Section: Discussionmentioning
confidence: 79%
“… 32 Furthermore, YTHDF3 levels were also found to be upregulated in the placentas of gestational diabetes mellitus (GDM), showing excellent classifying power for the GDM and control groups. 33 These findings indicate a critical role for the m6A readers YTHDF2 and YTHDF3 in the occurrence, progression, and prevention of DM, and could thus help to restore the damaged functions of DM-BMSCs to improve the success rate of implantation. However, the role of YTHDF2 and YTHDF3 in DM-BMSCs and their effects on the implant success rate require further exploration.…”
Section: Discussionmentioning
confidence: 79%
“…Researches had shown that lncRNA do not represent transcriptional noise. which played an essential role in tumors (34)(35)(36)(37). For example, autophagy-related lncRNA characteristics could accurately forecast the prognosis of patients with Bladder Cancer (38).…”
Section: Discussionmentioning
confidence: 99%
“…Several researchers performed high throughput sequencing and analyzed the data from GEO to explore the underlying mechanism of m 6 A in GDM. Du et al generated a lncRNA-mediated competitive endogenous RNA (ceRNA) network, and found that hub genes were mainly involved in fatty acid metabolism pathway, which play a role in the development and adverse outcomes of GDM ( Du et al, 2022a ). Other GDM-associated hormones were also enriched, such as thyroid hormone and oxytocin ( Du et al, 2022a ).…”
Section: Rna M 6 a In Great Obstetrical Syndromes ...mentioning
confidence: 99%
“…Du et al generated a lncRNA-mediated competitive endogenous RNA (ceRNA) network, and found that hub genes were mainly involved in fatty acid metabolism pathway, which play a role in the development and adverse outcomes of GDM ( Du et al, 2022a ). Other GDM-associated hormones were also enriched, such as thyroid hormone and oxytocin ( Du et al, 2022a ). In addition, m 6 A modified genes related to monocyte infiltration were also clinically important in GDM, including CD81, CFH, FABP5, GBP1 etc.…”
Section: Rna M 6 a In Great Obstetrical Syndromes ...mentioning
confidence: 99%