“…Genetic interactions have been predicted based on gene ontology information (Yu et al, 2016;Ma et al, 2018), mutation and expression data (Lee et al, 2018), protein-protein interaction (PPI) data (Hao et al, 2021) and by specifically-designed deep learning models (Ma et al, 2018;Cai et al, 2020). Gene dependencies have been predicted based on expression information (Itzhacky and Sharan, 2021;Lin and Lichtarge, 2021), pathway information (Lin and Lichtarge, 2021), genetic essentiality profiles (Wang et al, 2019), and PPI and genomic alteration information (Benstead-Hume et al, 2019). Drug sensitivity data have been predicted based drug structure information combined with gene ontology information (Kuenzi et al, 2020) or gene expression data (Wang et al, 2017;Zhang et al, 2018;Choi et al, 2020;Itzhacky and Sharan, 2021).…”