Biological monitoring of polycyclic aromatic hydrocarbon exposure in a highly polluted area of Poland.

Øvrebø, Steinar; Fjeldstad, Per Einar; Grzybowska, Ewa; Kure, Elin H.; Chorazy, M; Haugen, Aage

doi:10.1289/ehp.103-1519226

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…Urinary 1-OHP, a metabolite of PAHs, has been shown to be an indicator of both uptake of pyrene from foods and exposure to exogenous PAHs ( Jongeneelen 2001 ; Kanoh et al 1993 ; Ovrebo et al 1995 ). Moreover, the level of urinary 1-OHP has been shown to be correlated with genotoxic effects in coke oven workers as determined by a number of assays, including micronuclei frequency and DNA damage measured by sister-chromatid exchange and comet assays ( Siwinska et al 2004 ).…”

Section: Discussionmentioning

confidence: 99%

Using Lymphocyte and Plasma Hsp70 as Biomarkers for Assessing Coke Oven Exposure among Steel Workers

Yang

Zheng

Bai

et al. 2007

Environ Health Perspect

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BackgroundHsp70, an early-response protein induced when organisms are confronted with simple or complicated environmental stresses, can act as either a cellular protector or a danger signal.ObjectivesThe goal of this study was to evaluate levels of lymphocyte and/or plasma Hsp70 as biomarkers for assessing exposure response to complex coke oven emissions (COEs).MethodsWe recruited 101 coke oven workers and determined levels of polycyclic aromatic hydrocarbon (PAH) exposure, urinary 1-hydroxypyrene (1-OHP), genotoxic damage by comet assay and micronuclei test, and other markers of damage, including plasma malondialdehyde (MDA) and lactate dehydrogenase (LDH). These were compared to levels of lymphocyte (intra-cellular) and plasma (extracellular) Hsp70 using Western blots and enzyme-linked immunosorbent assays (ELISA), respectively.ResultsWe observed a COEs-related dose-dependent increase in levels of DNA damage, micronuclei rate, MDA concentration, and LDH activity. Lymphocyte Hsp70 levels increased in the intermediate-exposure group (1.39 ± 0.88) but decreased in the high-exposure group (1.10 ± 0.55), compared with the low-exposure group. In contrast, plasma Hsp70 levels progressively increased as the dose of exposure increased. Negative correlations were seen between lymphocyte Hsp70 levels and olive tail moment and LDH activity in the intermediate- and high-exposure groups. However, we observed positive correlations between plasma Hsp70 levels and LDH activity in the low and intermediate groups.ConclusionsIn workers exposed to COEs, high lymphocyte Hsp70 levels may provide protection and high plasma Hsp70 levels may serve as a danger marker. Larger validation studies are needed to establish the utility of Hsp70 as a response marker.

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Section: Discussionmentioning

confidence: 99%

Using Lymphocyte and Plasma Hsp70 as Biomarkers for Assessing Coke Oven Exposure among Steel Workers

Yang

Zheng

Bai

et al. 2007

Environ Health Perspect

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“…Exposure may be monitored through environmental samples and the use of biomarkers of exposure. [13][14][15][16] PAH exposure is a problem not confined specifically to Asia, yet it can be observed that it is relatively pronounced in Bangkok when compared to many other cities in the same as well as in other parts of the world. 11,[17][18][19][20][21] One of the assumptions in the studies conducted in our laboratory is that since PAH's are traffic-related air pollutants and are normally particle-associated, their concentrations should be highest near the source, that is, on the roads, and that the people most at risk are those who spend significant portions of their day directly at or very near these sources (TABLE 1).…”

Section: Pahsmentioning

confidence: 99%

“…There is evidence that 1-OHP may correlate better with relatively higher occupational exposures rather than environmental exposures. 15,16 PAH-DNA adducts represent both biomarkers of exposure and biomarkers of biologically effective dose since PAHs are metabolized to electrophilic intermediates, which bind to cellular macromolecules, such as DNA and proteins to form adducts. The formation of DNA adducts is believed to be the first step in the initiation of carcinogenesis.…”

Section: Pahsmentioning

confidence: 99%

Environmental Impacts on Children's Health in Southeast Asia

Ruchirawat

Navasumrit

Settachan

et al. 2006

Annals of the New York Academy of Sciences

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Air pollution is a serious problem in many countries in Southeast Asia, particularly in major metropolises with high levels of traffic congestion generating significant amounts of genotoxic substances. The contribution of such environmental exposure to children's illnesses, such as respiratory diseases and cancer, is a public health concern. Inner-city children may have higher levels of exposure to genotoxic substances in the air than those living in rural areas. This study was conducted in Bangkok, where ambient levels of polycyclic aromatic hydrocarbons (PAHs) and benzene are relatively high. Bangkok school children were exposed to total PAHs at about sixfold higher levels than those in rural areas, with levels of urinary 1-hydroxypyrene (1-OHP) also being significantly higher. PAH-DNA adduct levels in lymphocytes were fivefold higher in Bangkok children. Benzene exposure in Bangkok school children was more than twofold higher than the levels measured in children from the rural areas. This is in agreement with the biomarkers of internal dose, that is, blood benzene and urinary trans, trans-muconic acid (t,t-MA) levels. The potential health risks from exposure to PAHs and benzene were assessed through the use of DNA damage and DNA repair capacity as markers of early biological effect. DNA strand breaks were significantly higher in Bangkok school children, while DNA repair capacity was significantly lower. It appears that children in major cities in developing countries may have an increased health risk for the development of certain diseases, such as cancer due to exposure to genotoxic substances in their environment.

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“…석탄광산이 349개, 금속광산이 988개, 비금속광산이 699 개 등 총 2,036개 광산이 전국적으로 분포하고 있는 것으로 알려져 있다 (Jung et al, 2010 (Choi et al, 2010;Yun et al, 2011;Jang et al, 2011 (Cho et al, 1996;Kim et al, 1997;Min et al, 1997;Kim et al, 1998;Min et al, 2005;Lee et al, 2006;Park et al, 2007) (Ovrebo et al, 1995;Micic et al, 2007;Pies et al, 2007;Achten and Hofmann, 2009;Bandowe et al, 2010 (Zuo et al, 2007;Achten and Hofmann, 2009;Chen et al, 2011 (Choi et al, 2010;Yun et al, 2011;Jang et al, 2011) (Ovrebo et al, 1995;Micic et al, 2007;Pies et al, 2007;Achten and Hofmann, 2009;Bandowe et al, 2010)…”

Section: 서 론unclassified

Distribution Correlation between Heavy Metals Contaminants and PAHs Concentrations of Soils in the Vicinity of Abandoned Mines

Ki¹,

Park²,

et al. 2014

Korean Journal of Environmental Agriculture

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BACKGROUND: Heavy metals contamination of soils in the vicinity of abandoned mines in South Korea has been investigated. However, PAHs contamination rarely has been studied. Both heavy metals and PAHs concentrations have been measured in this study. METHODS AND RESULTS: The samples of soil and sediment were collected from the vicinities of three abandoned coal mines and two abandoned metal mines for analysis of heavy metals contaminants and PAHs concentration from April to September 2012. After preparation of these samples following the Korean standard test method for soils, the concentrations of heavy metals contaminants and PAHs were measured using ICP-OES and GC-MS, respectively. It was observed that the concentration of Arsenic was above the concern level based on 'area 1' suggested by Korean soil conservation law, resulting that Arsenic is the main contaminant in these areas. Also Cd, Cu, Pb and Zn were observed as a partial contaminants. The concentrations of other investigated components including benzo(a)pyrene were less than the concern level. CONCLUSION:The correlation observed between Arsenic (as main contaminant) and PAHs concentrations suggested that the contaminant source and pathway are different for each other. The effect of mine activity on PAHs concentration was rarely observed.

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Biological monitoring of polycyclic aromatic hydrocarbon exposure in a highly polluted area of Poland.

Cited by 3 publications

References 13 publications

Using Lymphocyte and Plasma Hsp70 as Biomarkers for Assessing Coke Oven Exposure among Steel Workers

Using Lymphocyte and Plasma Hsp70 as Biomarkers for Assessing Coke Oven Exposure among Steel Workers

Environmental Impacts on Children's Health in Southeast Asia

Distribution Correlation between Heavy Metals Contaminants and PAHs Concentrations of Soils in the Vicinity of Abandoned Mines

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