Biological Monitoring of Polycyclic Aromatic Hydrocarbon Exposure in a Highly Polluted Area of Poland

Øvrebø, Steinar; Fjeldstad, Per Einar; Grzybowska, Ewa; Kure, Elin H.; Chorazy, M; Haugen, Aage

doi:10.2307/3432397

Cited by 11 publications

(6 citation statements)

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“…Seasonal variation has also been observed in some studies (Ovrebo et al 1995). 1-OHPY did not differ in the age range of 1Á6 years (van Wijnen et al 1996).…”

Section: -Hydroxypyrenesupporting

confidence: 68%

Validation of biomarkers for the study of environmental carcinogens: a review

et al. 2008

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There is a need for validation of biomarkers. Our aim is to review published work on the validation of selected biomarkers: bulky DNA adducts, N-nitroso compounds, 1-hydroxypyrene, and oxidative damage to DNA. A systematic literature search in PubMed was performed. Information on the variability and reliability of the laboratory tests used for biomarkers measurements was collected. For the evaluation of the evidence on validation we referred to the ACCE criteria. Little is known about intraindividual variation of DNA adduct measurements, but measurements have a good repeatability irrespective of the technique used for their identification; reproducibility improved after the correction for a laboratory factor. A high-sensitivity method is available for the measurement of 1-hydroxypyrene in urine. There is consensus on validation of biomarkers of oxidative damage DNA based on the comet assay and chromatographic measurement in blood while urinary measurements by chromatographic assays are well validated, and ELISA-based assays appear to lack specificity. Immunoassays for the quantification of adducts of N-nitroso compounds are useful for large epidemiological studies, given their sensitivity, the small amount of DNA required and their potential for rapid and high-throughput analysis.

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“…Seasonal variation has also been observed in some studies (Ovrebo et al 1995). 1-OHPY did not differ in the age range of 1Á6 years (van Wijnen et al 1996).…”

Section: -Hydroxypyrenesupporting

confidence: 68%

Validation of biomarkers for the study of environmental carcinogens: a review

et al. 2008

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“…The urinary concentrations of most PAH metabolites were significantly higher in the exposed group than those in the control group, indicating that the participants from the polluted area were subjected to higher levels of PAH pollutants than those from the control area. The mean urinary 1-OHP concentration (1.96 μg/g creatinine for children, 1.42 μg/g creatinine for elderly nonsmokers, and 3.13 μg/g creatinine for elderly smokers) in the exposed population in the current study is comparable to that in children and adults living in a polluted area of Silesia, Poland (1.88 μg/g creatinine for children and 1.71−6.35 μg/g creatinine for adults), 27,28 lower than that in a Chinese general population living in a northern rural area of Jiangsu Province, China (6.35 μg/g creatinine for adults), 29 and higher than that in the American general population (0.164 μg/g creatinine for children and 0.122 μg/g creatinine for adults). 30 From these comparisons, we conclude the participants in the current study were exposed to moderate or relatively low levels of PAH pollutants.…”

Section: ■ Discussionsupporting

confidence: 62%

Human Metabolic Responses to Chronic Environmental Polycyclic Aromatic Hydrocarbon Exposure by a Metabolomic Approach

Wang

Zheng

Zhao³

et al. 2015

J. Proteome Res.

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The toxicities of polycyclic aromatic hydrocarbons (PAHs) have been extensively explored due to their carcinogenic and mutagenic potency; however, little is known about the metabolic responses to chronic environmental PAH exposure among the general population. In the present study, 566 healthy volunteers were dichotomized into exposed and control groups to investigate PAH-induced perturbations in the metabolic profiles. Nine urine PAH metabolites were measured by a sensitive LC-MS/MS method to comprehensively evaluate the PAH exposure level of each individual, and the metabolic profiles were characterized via a LC-MS-based metabolomic approach. PAH exposure was correlated to its metabolic outcomes by linear and logistic regression analyses. Metabolites related to amino acid, purine, lipid, and glucuronic acid metabolism were significantly changed in the exposed group. 1-Hydroxyphenanthrene and dodecadienylcarnitine have potential as sensitive and reliable biomarkers for PAH exposure and its metabolic outcomes, respectively, in the general population. These findings generally support the hypothesis that environmental PAH exposure causes oxidative stress-related effects in humans. The current study provides new insight into the early molecular events induced by PAH exposure in the actual environment.

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“…It should however be noted that, in most of the published studies, it has been reported that age and gender did not in¯uence the creatinine-adjusted urinary excretion of 1-OHP in the general population (Ovrebo et al 1995;Roggi et al 1997;Van Wijnen et al 1996;Zhao et al 1992a).…”

Section: Subjectsmentioning

confidence: 88%