Biological monitoring of lead exposure in high risk groups in Berat, Albania

Tabaku, Afrim; Bizgha, V; Rahlenbeck, Sibylle I.

doi:10.1136/jech.52.4.234

Cited by 9 publications

(3 citation statements)

References 25 publications

(22 reference statements)

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“…The scalp hair results of mothers and their infants are consistent with other studies conducted in the uncontaminated (6.0 and 5.3) μg/g and contaminated areas (13.3 and 7.2) μg/g, respectively [23]. Our results of maternal and infants blood Pb are consistent with other studies, i.e., Tabaku et al [25] (106, 89 μg/l) and Saxena et al [26] (194, 170 μg/l), while higher as compared to Al-Saleh et al [27] (55, 41 μg/l), Vasilios et al [28] (37, 20 μg/l), Lagerkvist et al [29], (26,22 μg/l), and Raghunathu et al [24] (64, 51 μg/l). The levels of Pb were found to be higher in urine samples of DM and their infants than referents (p< 0.015-0.02; Table 4; Fig.…”

Section: Elemental Analysis Of Biological Samplessupporting

confidence: 96%

Status of Toxic Metals in Biological Samples of Diabetic Mothers and Their Neonates

Kolachi

Kazi

Afridi

et al. 2010

Biol Trace Elem Res

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The mechanism of transport of trace elements from the mother to the newborn is still not well known. The aim of present study was to compare the status of trace toxic elements, arsenic (As), cadmium (Cd), and lead (Pb) in biological samples (whole blood, urine and scalp hair) of insulin-dependent diabetic mothers (age ranged 30-40) and their newly born infants (n = 76). An age and socioeconomics matched 68 nondiabetic mothers and their infants, residing in the same locality, who were selected as referents. The elemental concentrations in all three biological samples were determined by an electrothermal atomic absorption spectrometer, prior to microwave-assisted acid digestion. The mean values of As, Cd, and Pb in all biological samples of diabetic mothers and their infants were significantly higher as compared to the referent mother-infant pair samples (p < 0.01). The high levels of As, Cd, and Pb in biological samples of diabetic women may play a role in the pathogenesis of diabetes mellitus and impacts on their neonates.

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Section: Elemental Analysis Of Biological Samplessupporting

confidence: 96%

Status of Toxic Metals in Biological Samples of Diabetic Mothers and Their Neonates

Kolachi

Kazi

Afridi

et al. 2010

Biol Trace Elem Res

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“…In Mexico City, lead levels in blood range between 1 and 31 μg/dl; in ≤44% of children, contents >10 μg/dl are found (16). In some industrial areas of developing countries, lead levels are as high as 53 μg/dl (17).…”

Section: Discussionmentioning

confidence: 99%

Prolonged Exposure to Lead Lowers the Threshold of Pentylenetetrazole‐induced Seizures in Rats

et al. 2005

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Summary:Purpose: The aim of this work was to study the effects of prolonged exposure to lead on the threshold of experimental seizures induced by pentylenetetrazole (PTZ).Methods: The 120 Wistar male rats were allocated randomly into four groups; (A) controls, and lead-treatment groups (B, C, and D) that received lead acetate in the drinking water for a period of 30 days at concentrations of 250, 500, and 1,000 ppm, respectively. After exposure, a trial of PTZ-induced seizures was conducted in all groups, and blood contents of lead were determined by atomic absorption spectrophotometry.Results: Blood lead contents increased in a dose-dependent manner. Time elapsed to develop the first myoclonic jerk and the tonic-clonic seizure was less in all lead-exposed groups than in controls. This effect was greater in the groups administered 500 and 1,000 ppm of lead. The required doses of PTZ to induce myoclonic jerks and tonic-clonic seizures were lower in leadexposed rats than in controls.Conclusions: We found a reduction in the threshold for seizures in rats whose blood contents of lead were similar to those of humans from some areas of urban centers with high levels of air pollution.

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“…These aspects helped lengthen the period of latency, and diversified the clinical and prognostic manifestations. From the tables and the figure above it is apparent that most of the blood samples had lead levels above the population background levels (Christensen and Holst, 1988;Palloti et al, 1983;Claeys-Thoreau et al, 1983;Tabaku et al, 1990;Tabaku et al, 1998). The highest lead bloodlevels were determined in samples collected in June 1992, which ranged from 22.5 -91.6 µg/dl (mean 56.041 ± 13.857) whereas the lowest levels were determined in the samples collected in May 1996, and ranged from 10.0 -44.1 µg/dl (mean 18.982 ± 9.030).…”

Section: Lead Poisoning From Contaminated Flour Tabakumentioning

confidence: 98%

Lead poisoning from contaminated flour

Tabaku

2022

JBS

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Lead widespread use has resulted in extensive environmental contamination, human exposure and significant public health problems in many parts of the world. Young children are particularly vulnerable to the toxic effects of lead and can suffer profound and permanent adverse health impacts. Lead also causes long-term harm in adults, including increased risk of high blood pressure and kidney damage. Exposure to lead can occur by contaminated air, water, dust, food, or consumer products. Lead is a cumulative poison, which produces a series of effects on blood forming tissues, the digestive and nervous systems, and the kidneys. The aim of this paper was the determiation of lead in blood of poisoning persons, as well as on contaminated flour and in contaminated milk. Between 1992 and 1998 some rural districts of north and southern Albania reported several massive outbreaks of lead intoxication. Intoxications were associated with the use of contaminated flour originating from rural old mills, whose cracked grindstones were repaired by using lead as a filling material. Almost 6,000 individuals living in the affected areas were exposed to the toxic pollutant. However, only 236 individuals were checked for lead blood exposure levels. Of these, almost half revealed clinical signs of lead poisoning. Lead analytical determinations were performed in blood, milk, and flour samples from the area population by using atomic absorption spectrometry. Lead levels in blood varied from 7.1 μg/dl to 91.6 μg/dl. Mean blood lead concentrations according to the age-groups varied from 39.18 μg/dl to 44.99 μg/dl, whereas the average lead levels in flour samples were 42 ppm, while in blended bovine milk 0.6 ppm. The levels of lead in blood samples, as well as in flour and milk have resulted higher than TLVs levels acceptable by WHO.

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Biological monitoring of lead exposure in high risk groups in Berat, Albania

Abstract: Conclusions-Blood lead concentrations in children from Berat are comparatively high and abatement measures are needed. (J Epidemiol Community Health 1998;52:234-236)

Cited by 9 publications

References 25 publications

Status of Toxic Metals in Biological Samples of Diabetic Mothers and Their Neonates

Status of Toxic Metals in Biological Samples of Diabetic Mothers and Their Neonates

Prolonged Exposure to Lead Lowers the Threshold of Pentylenetetrazole‐induced Seizures in Rats

Lead poisoning from contaminated flour

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